ArticleSleep2025
Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.
Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12-Month-Old Mice: Protective Effects of D30.CNS neuroscience & therapeutics · 2026Article
- Review
- Article
- Article
- Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram.Scientific reports · 2026Article
- Reduced gray matter in the prefrontal cortex and hippocampus: a potential neuroanatomical feature of insomnia comorbid with anxiety.Frontiers in psychiatry · 2026Article
- Article
- Association between sleep duration and depressive symptoms among older adults in China: a national cross-sectional study.Frontiers in psychiatry · 2026Article
- Brief sleep disruption following hippocampus-dependent learning downscales interneuron synapses within lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
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7 authors.
Funding
Abstract
STUDY
objectivesBrief sleep loss alters cognition and synaptic structures of principal neurons in the hippocampus and neocortex. However, while in vivo recording and bioinformatic data suggest that inhibitory interneurons are more strongly affected by sleep loss, it is unclear how sleep and sleep deprivation (SD) affect interneurons' synapses. Disruption of the somatostatin-expressing (SST+) interneuron population seems to be a critical early sign of neuropathology in Alzheimer's dementia, schizophrenia, and bipolar disorder-and the risk of developing all three is increased by habitual sleep loss. We aimed to test how the synaptic structures of SST+ interneurons in various brain regions are affected by brief sleep disruption.
methodsWe used Brainbow 3.0 to label SST+ interneurons in the dorsal hippocampus, prefrontal cortex, and visual cortex of male SST-CRE transgenic mice, then compared synaptic structures in labeled neurons after a 6-hour period of ad lib sleep, or gentle handling SD starting at lights on.
resultsDendritic spine density among SST+ interneurons in both hippocampus and neocortex was altered in a subregion-specific manner, with increased overall and thin spine density in CA1, dramatic increases in spine volume and surface area in CA3, and small but significant changes (primarily decreases) in spine size in CA1, PFC, and V1.
conclusionsWe suggest that the synaptic connectivity of SST+ interneurons is significantly altered in a brain region-specific manner by a few hours of sleep loss. This suggests a cell type-specific mechanism by which sleep loss disrupts cognition and alters excitatory-inhibitory balance in brain networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.