Evidence map›Paper›PMID 40096597›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The TEA domain transcription factors TEAD1 and TEAD3 and WNT signaling determine HLA-G expression in human extravillous trophoblasts.

Bowen Gu, Leonardo M R Ferreira, Sebastian Herrera, Lara Brown, Judy Lieberman, Richard I Sherwood, Torsten B Meissner, Jack L Strominger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Crosstalk of extracellular vesicles in maternal-fetal interaction.Frontiers in cell and developmental biology · 2026
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bowen GuDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Leonardo M R FerreiraDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425.
Sebastian HerreraDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
Lara BrownDivision of Genetics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA 02115.
Judy LiebermanProgram in Cellular and Molecular Medicine Boston Children's Hospital, Boston, MA 02115.ORCID 0000-0002-6200-4715
Richard I SherwoodDivision of Genetics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA 02115.
Torsten B MeissnerDepartment of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Jack L StromingerDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0002-5028-8415

Funding

Decidual NK response to infectionR01AI145862 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LIEBERMAN, JUDY · 2019 to 2023
$4.2M
High-throughput investigation of human genetic variants affecting cholesterol uptake and effluxR01HL164409 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHERWOOD, RICHARD I · 2022 to 2025
$3.1M
Development of potent and predictable Cas9 gene activation tools through high-throughput screeningR01GM143249 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SHERWOOD, RICHARD I · 2022 to 2024
$1.3M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI145862NHLBI NIH HHS R01 HL164409NIAID NIH HHS R01 AI145862NIGMS NIH HHS R01 GM143249
6 · The paper itself

Abstract

Maternal-fetal immune tolerance guarantees a successful pregnancy throughout gestation. HLA-G, a nonclassical human leukocyte antigen (HLA) molecule exclusively expressed in extravillous trophoblasts (EVT), is a crucial factor in establishing maternal-fetal immune tolerance by interacting with inhibitory receptors on various maternal immune cells residing in the uterus. While trophoblast-specific cis-regulatory elements impacting

Indexed as

DNA-Binding ProteinsHLA-G AntigensNuclear ProteinsTranscription FactorsTrophoblastsWnt Signaling PathwayExtravillous TrophoblastsFemaleGene Expression RegulationHumansImmune TolerancePregnancyTEA Domain Transcription FactorsDNA-Binding ProteinsHLA-G AntigensNuclear ProteinsTEAD1 protein, humanTEA Domain Transcription FactorsTranscription FactorsHLA-GpregnancyTEAD1TEAD3WNT signaling

Identifiers

PMID40096597
PMCPMC11962456

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.