ArticleLa Tunisie medicale2025
Impact of Demographic Factors on the Treatment Response of Antidepressant Therapy: A Descriptive Cohort Study from Pakistan.
Article in La Tunisie medicale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07654179 (Efficacy of Metformin With Antidepressant Medication as Adjunct Therapy in Depression-obesity Ccomorbidity and Ssociation With NEGR1/RPL31P12 Variants Based on Genotyping), which is not on this map. Cited by 2 papers.
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Efficacy of Metformin With Antidepressant Medication as Adjunct Therapy in Depression-obesity Ccomorbidity and Ssociation With NEGR1/RPL31P12 Variants Based on Genotyping
Open the trial in the graphWho cites it
2 citing papers in PubMed.
- Clinical evaluation of adjunctive magnesium therapy in patients receiving antidepressants for depression-open label, nonrandomized clinical trial.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Antidepressant prescribing patterns and patient-reported adverse effects: a cross-sectional study from Pakistan.Annals of general psychiatry · 2026Article
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6 authors.
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Abstract
introductionThe study is conducted in Pakistan to evaluate the impact of socio-demographic factors that might influence the treatment response to antidepressants in depressive disorder. Moreover, this study brings data from a South Asian developing country, to compete the existing literature gap, where the response to antidepressant treatment with respect to demographic factors is mostly from the western countries.
aimA prospective, open-label, descriptive cohort study is designed to signify the association of demographic factors on the treatment response of antidepressants.
methodsThe patients presented to outpatient department (OPD) of Psychiatry clinic at Pakistan Railway Hospital, Rawalpindi from October 05, 2022 to July 31, 2023 were included in the study. All the patients were diagnosed by a Consultant Psychiatrist, according to ICD-11 and were prescribed an antidepressant therapy. The demographic factors were divided into sub-categories i.e. age, gender, marital status, income status, geographical location, education, and comorbid conditions. The change in depressive scores were measured by Patient Health Questionnaire 9 (PHQ-9) on day 0, and 28. The data was analyzed using SPSS and results are reported in the subsequent section.
resultsOut of 88 patients, depression was found most widespread among females, married individuals, illiterate, above 41 years of age with comorbid conditions. The response to treatment was better in males (49.84%), single individuals (49.24%), educated (43.70%), and senior citizens (46.19%) in terms of percentage improvement.
conclusionsIt was concluded that the response to treatment was different among different subcategories in terms of percentage improvement. Female, illiterate, and single/divorced/widowed populations showed poor response to treatment. Moreover, geriatric population response was better as compared to all other age group. The patients having different comorbid conditions are more prone to develop depression, but the response to antidepressant therapy was comparable to those without any systemic illness.
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