Evidence map›Paper›PMID 40097341›Full record

Observational studyRenal failure2025

Long nighttime sleep duration and risk of renal tubular damage: evidence from rural China and a Mendelian randomization analysis.

JingJing Quan, Li Chen, Weilin Chen, Ziwei Gong, Si Li, Hengbing Chen, Zhijun Huang, Bin Yi

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

JingJing QuanDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Li ChenDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Weilin ChenDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ziwei GongDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
Si LiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Hengbing ChenDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhijun HuangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Bin YiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRenal tubular damage, a pivotal pathological feature of chronic kidney disease (CKD), predicts disease progression. While extreme nighttime sleep duration is linked to glomerular injury by prior studies, its impact on tubular damage remains unclear. Given that 7-9 h of sleep per night is widely recommended for maintaining overall health, this study aimed to assess whether long nighttime sleep duration is associated with renal tubular damage using both observational and genetic evidence.

methodsWe analyzed 2,683 adults in rural China to assess the link between nighttime sleep duration and renal tubular damage (measured by retinol-binding protein and β2-microglobulin). Mendelian randomization (MR) analysis was performed to assess the causal relationship between prolonged nighttime sleep duration and elevated kidney injury molecule-1 (KIM-1) levels.

resultsMultivariate logistic regression indicated that sleeping more than 9 h per night was associated with a 1.38-fold increased risk of renal tubular damage (95% CI: 1.11-1.71) compared to 7-9 h of sleep, with particularly pronounced effects observed in elderly individuals and women. MR analysis further supported a causal relationship between genetically predicted long nighttime sleep duration and elevated KIM-1 levels (

conclusionsOur findings provide observational and genetic evidence linking prolonged nighttime sleep to increased renal tubular damage risk. Given that 7-9 h of sleep per night is the widely accepted recommendation for maintaining overall health, our results emphasize the potential risks of excessive sleep duration exceeding 9 h.

Indexed as

Hepatitis A Virus Cellular Receptor 1Kidney TubulesRenal Insufficiency, ChronicSleepAdultAgedbeta 2-MicroglobulinChinaFemaleHumansMaleMendelian Randomization AnalysisMiddle AgedRetinol-Binding ProteinsRisk FactorsRural Populationbeta 2-MicroglobulinHAVCR1 protein, humanHepatitis A Virus Cellular Receptor 1Retinol-Binding Proteinsbiomarkerschronic kidney diseaseMendelian randomizationNighttime sleep durationrenal tubular damage

Identifiers

PMID40097341
PMCPMC11915733

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.