Evidence map›Paper›PMID 40097481›Full record

SynthesisScientific reports2025

Genome-wide association and multi-omics analyses provide insights into the disease mechanisms of central serous chorioretinopathy.

Yuki Mori, Elon H C van Dijk, Masahiro Miyake, Yoshikatsu Hosoda, Anneke I den Hollander, Suzanne Yzer, Akiko Miki, Li Jia Chen, Jeeyun Ahn, Ayako Takahashi and 21 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Yuki Mori *Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.
Elon H C van Dijk *Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Masahiro MiyakeDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan. miyakem@kuhp.kyoto-u.ac.jp.
Yoshikatsu HosodaHosoda Eye Clinic, Nishinomiya, Japan.
Anneke I den HollanderGenomics Research Center, Abbvie, Cambridge, MA, USA.
Suzanne YzerDepartment of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Akiko MikiDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Li Jia ChenDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Jeeyun AhnSeoul National University, College of Medicine, Seoul, Korea.
Ayako TakahashiDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.
Kazuya MorinoDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.
Shin-Ya NakaoDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.
Carel B HoyngDepartment of Ophthalmology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Danny S C NgDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Ling-Ping CenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Haoyu ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Tsz Kin NgJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Chi Pui PangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Kwangsic JooSeoul National University, College of Medicine, Seoul, Korea.
Takehiro SatoDepartment of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yasuhiko SakataDepartment of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Japan.
Atsushi TajimaDepartment of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yasuharu TabaraCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nagahama Study Group
Kyu Hyung ParkSeoul National University, College of Medicine, Seoul, Korea.
Fumihiko MatsudaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kenji YamashiroDepartment of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku, Japan.
Shigeru HondaDepartment of Ophthalmology and Visual Sciences, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Masao NagasakiCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Camiel J F BoonDepartment of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.
Akitaka TsujikawaDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Shogoin-kawahara, Sakyo, Kyoto, 606-8507, Japan.

Funding

Japan Agency for Medical Research and Development JP16dk0207006Japan Agency for Medical Research and Development JP16ek0109070Japan Agency for Medical Research and Development JP17ek0109196Japan Agency for Medical Research and Development JP17ek0210066Japan Agency for Medical Research and Development JP18ek0210096Japan Agency for Medical Research and Development JP18kk0205008Japan Agency for Medical Research and Development JP18le0110005Japan Agency for Medical Research and Development JP19ek0109283Japan Agency for Medical Research and Development JP19ek0210081Japan Agency for Medical Research and Development JP19le0110013Japan Agency for Medical Research and Development JP20dk0207027Japan Agency for Medical Research and Development JP20ek0109348Japan Agency for Medical Research and Development JP21ek0210116Japan Agency for Medical Research and Development JP21tm0724602Japan Agency for Medical Research and Development JP22dk0110040Japan Agency for Medical Research and Development JP22ek0210146Japan Agency for Medical Research and Development JP22tm0724604Japan Society for the Promotion of Science JP17H04123Japan Society for the Promotion of Science JP17H04126Japan Society for the Promotion of Science JP17H04182Japan Society for the Promotion of Science JP18K18450Japan Society for the Promotion of Science JP19K17634Japan Society for the Promotion of Science JP20H03841Japan Society for the Promotion of Science JP25293141Japan Society for the Promotion of Science JP26293198Japan Society for the Promotion of Science JP26670313"Joint Usage/Research Center for Interdisciplinary Large-scale Information Infrastructures" and "High Performance Computing Infrastructure" in Japan jh200047-NWH"Joint Usage/Research Center for Interdisciplinary Large-scale Information Infrastructures" and "High Performance Computing Infrastructure" in Japan jh210018-NWH"Joint Usage/Research Center for Interdisciplinary Large-scale Information Infrastructures" and "High Performance Computing Infrastructure" in Japan jh220014
6 · The paper itself

Abstract

Central serous chorioretinopathy (CSC) is a major cause of vision loss, especially in middle-aged men, and its chronic subtype can lead to legal blindness. Despite its clinical importance, the underlying mechanisms of CSC need further clarification. In this study, we conducted a meta-analysis of three genome-wide association studies (GWASs) for CSC consisting of 8811 Asians and Caucasians, followed by replication in an additional 4338 Asians. We identified four genome-wide hits, including a novel hit (rs12960630 at LINC01924-CDH7, P

Indexed as

Central Serous ChorioretinopathyGenome-Wide Association StudyAllelesAsian PeopleFemaleGenetic Predisposition to DiseaseHumansMaleMultiomicsPolymorphism, Single NucleotideQuantitative Trait LociWhite People

Identifiers

PMID40097481
PMCPMC11914043

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.