Evidence map›Paper›PMID 40098005›Full record

ReviewJournal of nanobiotechnology2025

Functions and application of circRNAs in vascular aging and aging-related vascular diseases.

Sha-Qi He, Bei Huang, Feng Xu, Jun-Jie Yang, Cong Li, Feng-Rong Liu, Ling-Qing Yuan, Xiao Lin, Jun Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sha-Qi He *Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Bei Huang *Department of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Feng XuNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Jun-Jie YangDepartment of Radiology, the Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, 830054, China.
Cong LiDepartment of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Feng-Rong LiuDepartment of Anesthesiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Ling-Qing YuanNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Xiao LinDepartment of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China. daisylx8990@csu.edu.cn.
Jun LiuDepartment of Radiology, the Second Xiangya Hospital of Central South University, Changsha, 410011, China. junliu123@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs), constituting a novel class of endogenous non-coding RNAs generated through the reverse splicing of mRNA precursors, possess the capacity to regulate gene transcription and translation. Recently, the pivotal role of circRNAs in controlling vascular aging, as well as the pathogenesis and progression of aging-related vascular diseases, has garnered substantial attention. Vascular aging plays a crucial role in the increased morbidity and mortality of the elderly. Endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are crucial components of the intima and media layers of the vascular wall, respectively, and are closely involved in the mechanisms underlying vascular aging and aging-related vascular diseases. The review aims to provide a comprehensive exploration of the connection between circRNAs and vascular aging, as well as aging-related vascular diseases. Besides, circRNAs, as potential diagnostic markers or therapeutic targets for vascular aging and aging-related vascular diseases, will be discussed thoroughly, along with the challenges and limitations of their clinical application. Investigating the role and molecular mechanisms of circRNAs in vascular aging and aging-related vascular diseases will provide a novel insight into early diagnosis and therapy, and even effective prognosis assessment of these conditions.

Indexed as

AgingRNA, CircularVascular DiseasesAnimalsBiomarkersEndothelial CellsHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleBiomarkersRNA, CircularAging-related vascular diseasescircRNAsEndothelial cellsVascular agingVascular smooth muscle cells

Identifiers

PMID40098005
PMCPMC11917153

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.