ArticleInternational journal of nanomedicine2025
3D-Printed Poly (Lactic-Co-Glycolic Acid) and Graphene Oxide Nerve Guidance Conduit with Mesenchymal Stem Cells for Effective Axon Regeneration in a Rat Sciatic Nerve Defect Model.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Biomaterial-assisted neuralization strategies for tissue engineering applications.Materials today. Bio · 2026Review
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9 authors.
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Abstract
Introduction: Peripheral nerve injuries (PNIs) impact the quality of life of millions of people. The current gold standard of treatment, the autograft, fails to restore nerve function and is often associated with untoward effects. The alternative interventions available remain unable to ensure full functional recovery. For this study we developed a 3D printed nerve guidance conduit (NGC) composed of poly (lactic-co-glycolic acid) (PLGA) and 0.25% graphene oxide (GO), that can be seeded with human adipose-derived mesenchymal stem cells (MSCs), to develop a more effective treatment for PNI. Methods: We evaluated material degradation, surface topography, and MSC attachment in vitro. For the in vivo analyses, a 10-mm long sciatic nerve defect model was created, and rats were randomly divided into 4 treatment groups: autograft, PLGA, PLGA/GO, and PLGA/GO with 1×10 Results: In vitro results showed expected degradation rates, and the addition of GO exhibited cytocompatibility and favorable cell attachment. In vivo results showed biocompatibility with no translocation of the graphene nanoparticles. Histology showed evidence of axonal and myelin sheath repair. Biomechanics and gross muscle analyses had contradicting evidence of functional repair with the addition of GO. No differences were seen with the addition of MSCs. Conclusion: Our novel PLGA/GO NGC, both with and without MSCs, showed results comparable to or greater than the current gold standard, as well as ease of use surgically. With further studies to validate functional recovery, this specific combination of PLGA and GO may provide an effective biomimetic therapy to repair PNIs.
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