ArticleInternational journal of nanomedicine2025
Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Advances in Nanozyme Engineering for Precision Oral Health Management.International dental journal · 2026Review
- NIR-Activated ICG-Loaded M2 Macrophage Exosomes Ameliorate Periodontitis via Targeting Infection Inflammation and Oxidative Stress.Research (Washington, D.C.) · 2026Article
- The Incorporation of CBD into Biodegradable DL-Lactide/Glycolide Copolymers Creates a Persistent Antibacterial Environment: An In Vitro Study onPharmaceutics · 2025Article
- Oral stem cells in combination with hydrogels as biomimetic bioactive platforms for periodontal tissue engineering.Frontiers in oral health · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontitis, one of the most common oral diseases caused by bacterial infection which affects gums, periodontal ligament and alveolar bone, is a leading cause of tooth loss in adults. Current clinical treatments, such as scaling or antibiotics, often result in incomplete biofilm removal or can contribute to drug resistance. Methods: To address these limitations, a nanozyme comprising platinum, copper, and selenium was developed, which was then incorporated into a thermoresponsive hydrogel. Results: When applied to periodontal pockets and exposed to 808 nm laser irradiation, the hydrogel became soft, dissolving to release the nanozyme. This nanozyme demonstrated superoxide dismutase (SOD)-like and catalase (CAT)-like activity, reducing excess reactive oxygen species (ROS) while displaying strong antibacterial and anti-inflammatory effects. Conclusion: This photothermal nanozyme hydrogel showed excellent biocompatibility and has the potential to overcome the challenges of current periodontitis treatments.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.