Evidence map›Paper›PMID 40099149›Full record

ArticleImmunoTargets and therapy2025

Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways.

Shafiya Imtiaz Rafiqi, Ahmad Aldasouqi, Rodis D Paparodis, Sandesh Dewan, Aneeba Farooqi, Sarah Faisal, Yousuf Nemat, Nancy Salim, Salauddin Qureshi, Asif Mahmood and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ImmunoTargets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shafiya Imtiaz RafiqiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.ORCID 0000-0003-3093-9724
Ahmad AldasouqiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Rodis D PaparodisHellenic Endocrine Network, Athens, Greece, Endocrinology, Diabetes and Metabolism Clinics, Private Practice, Patras, Greece.ORCID 0000-0003-2804-0859
Sandesh DewanDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Aneeba FarooqiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Sarah FaisalDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Yousuf NematDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Nancy SalimDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Salauddin QureshiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Asif MahmoodUniversity of Toledo Medical Centre, Hospital Medicine, University of Toledo, Toledo, OH, USA.
Yara TovarDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
John Y JunDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.
Andrea L KalinoskiDepartment of Surgery, Integrated Core Facilities, University of Toledo, Toledo, OH, USA.ORCID 0000-0002-1475-3578
Raghavendra G MirmiraDivision of the Biological Sciences, the University of Chicago, Chicago, IL, USA.ORCID 0000-0002-5013-6075
Juan Carlos JaumeStritch School of Medicine/Edward Hines, Jr. VA Hospital, Loyola University Chicago, Hines, IL, USA.
Shahnawaz ImamDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, USA.ORCID 0000-0003-4700-5370

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
Role of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and ReplicationR01DK124906 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2020 to 2026
$4.0M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK124906
6 · The paper itself

Abstract

Background: The generation of functionally active, stable T regulatory cells (Tregs) is a crucial target of type 1 diabetes (T1D) immunotherapy. This study investigated therapeutic intervention for T1D/Latent autoimmune diabetes in adults (LADA), wherein the diabetogenic proinflammatory Treg (intermediate) cell subset was characterized and driven to a Treg phenotype (CD4 Methods: Peripheral blood from patients with T1D/LADA and healthy adults (n=7 each) was used to isolate the CD4 Results: A unique population of proinflammatory cytokines expressing intermediate Tregs (CD4

Indexed as

autoimmune disorderseIF5aimmune cell plasticityimmunomodulationlatent autoimmune diabetes in adultsnotchtransdifferentiationtype 1 diabetesunfit tregs

Identifiers

PMID40099149
PMCPMC11912933

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.