Trial reportArthritis care & research2025
Association of Pain During Exercise With Exercise-Induced Hypoalgesia in People With Knee Osteoarthritis.
Trial report in Arthritis care & research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effects of a Cycling-Based Aerobic Exercise Program Versus a Resistance and Neuromuscular Exercise Program on Exercise-Induced Hypoalgesia in Knee Osteoarthritis: A Study Protocol for a Randomized Clinical Trial.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Motion as Medicine: Physical Activity, Joint Sensitivity, and Pain Management-A Narrative Review.Medical sciences (Basel, Switzerland) · 2026Review
- Blunted exercise-induced hypoalgesia in people with knee pain after a brief low-intensity warm-up: a split-body study with and without blood flow restriction.BMC sports science, medicine & rehabilitation · 2026Article
- Biological, biomechanical, and pain sensitivity effects of walk-run in people with self-reported knee osteoarthritis.Frontiers in sports and active living · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveA paradoxical relationship between pain during exercise and the hypoalgesic effect of exercise has not been studied well in the knee osteoarthritis (OA) population. We sought to investigate the relation of pain evoked during exercise to exercise-induced hypoalgesia (EIH) and to determine if the efficiency of conditioned pain modulation (CPM), a proxy of the descending pain inhibitory system, mediates this relationship in people with knee OA.
methodsWe used baseline data from two clinical trials for people with symptomatic knee OA (n = 68). The maximum pain rating (0-10) during a series of knee exercises was defined as the outcome. EIH was assessed as an increase (ie, improvement) in the pressure pain threshold (PPT) after a bout of exercises. Efficient CPM was defined as an increase (ie, improvement) in PPT after a painful conditioning stimulus (forearm ischemia). We performed a causal mediation analysis to examine the association between pain during exercise and EIH as well as the mediating role of CPM efficiency on the relation of pain during exercise with EIH.
resultsPeople with knee OA who had at least a one-unit increase in pain with exercise were 43% more likely (odds ratio [OR] 1.43, 95% confidence interval [CI] 1.05-1.94) to experience subsequent EIH than those without pain increase. The efficiency of CPM did not mediate the relationship between pain during exercise and EIH (OR 1.00, 95% CI 0.96-1.04).
conclusionOur finding suggests that some amount of discomfort or pain during exercise may have beneficial analgesic effects; however, this is not likely via activation of the descending pain inhibitory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.