Evidence map›Paper›PMID 40099884›Full record

ArticlemSphere2025

Toxoplasmosis accelerates the progression of hereditary spastic paraplegia.

James R Alvin, Carlos J Ramírez-Flores, Caitlin A Mendina, Anjon Audhya, Laura J Knoll, Molly M Lettman

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James R AlvinDepartment of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Carlos J Ramírez-FloresDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Caitlin A MendinaDepartment of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Anjon AudhyaDepartment of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Laura J KnollDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0002-9362-8088
Molly M LettmanDepartment of Biomolecular Chemistry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0003-1472-5662

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Molecular mechanisms that regulate vesicle formation and transportR35GM134865 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya · 2020 to 2026
$4.8M
Graduate Training in Molecular and Cellular PharmacologyT32GM141013 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya, Aaron Matthew LeBeau · 2021 to 2026
$3.2M
Mechanisms Underlying Axonopathy in Hereditary Spastic ParaplegiaR01NS124165 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya · 2022 to 2026
$1.9M
HHS | National Institutes of Health (NIH) NS124165HHS | National Institutes of Health (NIH) P30 CA014520, P50 HD105353NCI NIH HHS P30 CA014520NICHD NIH HHS P50 HD105353NIGMS NIH HHS R35 GM134865NIGMS NIH HHS T32 GM141013NINDS NIH HHS R01 NS124165
6 · The paper itself

Abstract

The parasitic protozoa

Indexed as

Spastic Paraplegia, HereditaryToxoplasmosisToxoplasmosis, AnimalAnimalsDisease Models, AnimalDisease ProgressionFemaleMaleRatsToxoplasmachronic infectionhereditary spastic paraplegianeurodegenerationToxoplasma

Identifiers

PMID40099884
PMCPMC12039240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.