Evidence map›Paper›PMID 40100296›Full record

ArticlePediatric cardiology2026

Holodiastolic Flow Reversal in the Descending Aorta: A Marker of Concomitant Acute Myocarditis and Aortitis in Children-A Case Series.

Elaheh Malakan Rad, Hamidreza Pourlaiakbar, Mojtaba Gorji, Ziyad M Hijazi

Abstract readCase Reports
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In one paragraph

Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elaheh Malakan RadResearch Center for the Prevention of Cardiovascular Diseases and the Promotion of Fetal, Pediatric, and Adolescent Cardiovascular Health, Affiliated with Tehran University of Medical Sciences (TUMS), No.62, Dr. Gharib's Street, End of Keshavarz Boulevard, Tehran, 1419733151, Iran. erad@tums.ac.ir.ORCID http://orcid.org/0000-0001-7824-6973
Hamidreza PourlaiakbarShahid Rajaei Cardiovascular Medical and Research Institute, Tehran, Iran.
Mojtaba GorjiResearch Center for the Prevention of Cardiovascular Diseases and the Promotion of Fetal, Pediatric, and Adolescent Cardiovascular Health, Affiliated with Tehran University of Medical Sciences (TUMS), No.62, Dr. Gharib's Street, End of Keshavarz Boulevard, Tehran, 1419733151, Iran.
Ziyad M HijaziUniversity of Jordan, Amman, Jordan.ORCID http://orcid.org/0000-0002-0072-6034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case series describes five pediatric patients with acute myocarditis presenting holodiastolic flow reversal in the descending aorta despite the absence of aortic run-off lesions. This Doppler finding highlights the role of aortitis or Concomitant Acute Myocarditis and Aortitis (CAMA). Cardiac magnetic resonance imaging (MRI) with late gadolinium enhancement (LGE) confirmed myocarditis in three cases. Key findings included poor response to exogenous catecholamines, elevated troponin I, hyponatremia, low vitamin D, and frequent biventricular involvement. Outcomes included one successful cardiac transplantation, one requiring levosimendan, and three fatalities. Low diastolic blood pressure and flow reversal in the descending aorta are critical clues for diagnosing CAMA. Clinical implications, pathophysiology, and management are discussed.

Indexed as

Aorta, ThoracicAortitisMyocarditisAcute DiseaseAdolescentChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleAortitisDescending aortaHolodiastolic flow reversalMyocarditisPediatric

Identifiers

PMID40100296

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.