Evidence map›Paper›PMID 40100474›Full record

ArticleNeurochemical research2025

OSGEP, A Negative Ferroptotic Regulator, Alleviates Cerebral Ischemia-Reperfusion Injury Through Modulating m

Cheng Chen, Wanqing Zhou, Qian Zhang, Dehao He, Yanfei Zhao, Zhuoyi Liu, Pingping Xia, Qing Li, Zhi Ye

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng ChenDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Wanqing ZhouDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Qian ZhangDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Dehao HeDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Yanfei ZhaoDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Zhuoyi LiuDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Pingping XiaDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China.
Qing LiDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhi YeDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan Province, China. yezhi523@csu.edu.cn.

Funding

National Natural Science Foundation of China 81973401National Natural Science Foundation of China 82001393National Natural Science Foundation of China 82371477Natural Science Foundation of Hunan Province 2021JJ3119
6 · The paper itself

Abstract

Cerebral ischemia-reperfusion injury (CIRI) is a devastating condition that triggers neuronal death and cerebral infarction. O-sialoglycoprotein endopeptidase (OSGEP), identified as a crucial element of the highly conserved KEOPS complex, regulated cellular proliferation and mitochondrial metabolism. Despite its known role in cellular homeostasis, the potential contribution of OSGEP to the development of CIRI remains elusive. This study was designed to investigate the potential role of ferroptosis in the pathogenesis of CIRI and indicate whether OSGEP could suppress ferroptosis to alleviate CIRI by modulating GPX4 m

Indexed as

AdenosineBrain IschemiaFerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseReperfusion InjuryRNA, MessengerAnimalsCells, CulturedHumansInfarction, Middle Cerebral ArteryMaleMethylationMiceMice, Inbred C57BLNeuronsAdenosineglutathione peroxidase 4, mouseN-methyladenosinePhospholipid Hydroperoxide Glutathione PeroxidaseRNA, MessengerCerebral ischemia–reperfusion injury (CIRI)FerroptosisGPX4m6AO-sialoglycoprotein endopeptidase (OSGEP)

Identifiers

PMID40100474

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.