Humanized Mouse Model of Graft-Versus-Host Disease Utilizing Nonirradiated NOD-scid-IL-2Rγ

Amal Elhage, Chloe Sligar, Debbie Watson, Ronald Sluyter

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Adeno-associated viral vectors encoding anti-P2X7 nanobodies reduce graft-versus-host disease in a humanised mouse model.Clinical & translational immunology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amal ElhageMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia. aelhage@uow.edu.au.ORCID https://orcid.org/0000-0003-0625-3183

Chloe SligarMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0002-9214-0742

Debbie WatsonMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0002-6242-3944

Ronald SluyterMolecular Horizons and School of Science, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0003-4909-686X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humanized mouse models of graft-versus-host disease (GVHD), involving the injection of human immune cells into immunodeficient mice, are firmly established and offer avenues for exploring pathways implicated in GVHD development and for testing therapeutics to prevent or treat this disease. NOD-scid-IL-2Rγ

Indexed as

Disease Models, AnimalGraft vs Host DiseaseInterleukin Receptor Common gamma SubunitAnimalsCytokinesFlow CytometryHumansMiceMice, Inbred NODMice, SCIDCytokinesInterleukin Receptor Common gamma SubunitAllogeneic hematopoietic stem cell transplantationCytokineFlow cytometryHumanized mouse modelHuman peripheral blood mononuclear cellLeukocyteNSG mouseXenogeneic graft-versus-host disease

Identifiers

PMID40100599

DOI10.1038/ncomms12150

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.