ArticleAJNR. American journal of neuroradiology2025
Concordance between Centiloid Quantification and Visual Interpretation of Amyloid PET Scans across the Alzheimer Disease Continuum.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Long term clinical performance and analytical robustness of the Lumipulse plasma p-tau217 assay in routine clinical practice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Liver steatosis and cognitive performance in aging: A pilot cross-sectional study.Clinical imaging · 2026Article
- Optimized Quantitative Susceptibility Mapping at 7T MRI for Assessing Iron Deposition in Alzheimer's Disease.NMR in biomedicine · 2026Article
- Amyloid PET quantification with deep learning segmentation models without MRI.EJNMMI physics · 2026Article
- Comparison of visual and analytic methods of Alzheimer's disease pathologic staging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Visual read performance ofAlzheimer's & dementia (Amsterdam, Netherlands)Article
- Diagnostic utility of plasma p-tau217 differs by Alzheimer's disease tau-based subtypes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Characterizing Japanese older adults without dementia by amyloid PET status: A comparative study of amyloid-positive and amyloid-negative groups from Japanese trial-ready cohort study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Factors associated with discordant visual and quantitative amyloid PET results.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Quantification of global gray matter amyloid-β plaque fromAlzheimer's & dementia (Amsterdam, Netherlands)Article
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14 authors.
Funding
Abstract
background and purposeAccurate identification of cerebral β-amyloid (Aβ) accumulation is crucial for diagnosing Alzheimer disease (AD) and determining eligibility for anti-Aβ therapies. The Centiloid (CL) scale has emerged as a standardized method to harmonize Aβ PET quantification across different tracers and sites. We aimed to evaluate the concordance between CL quantification and visual interpretation in a cohort of cognitively impaired (CI) and unimpaired (CU) participants who underwent Aβ PET. MATERIALS AND
methodsTwo hundred twenty-one participants (mean age 69 ± 12.3 years) were prospectively enrolled in AD studies and underwent 247 Aβ PET scans, including 157 with [
resultsThe highest concordance rate for the whole cohort was 93% by using a CL cutoff of 18 (κ coefficient 0.84). Using FBB, the concordance rate was highest by using a CL cutoff of 24 (97%), whereas the concordance rate for PiB peaked at 94% at a CL cutoff of 18. Concordance was higher in negative rather than positive Aβ PET cases, 98% versus 90%. Concordance was slightly higher in CI participants compared with CU (96% versus 93%). Disagreement commonly occurred when focal areas of Aβ positivity were identified on visual interpretation but did not meet the threshold globally by CL quantification.
conclusionsGlobal CL quantification of Aβ PET scans is highly concordant with visual interpretation. Combining both methods may provide a more complete assessment of the extent of Aβ deposition in the brain.
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