ArticleBMC ophthalmology2025
Corneal cross-linking effects on ocular surface parameters and corneal topographic and optical characteristics in progressive keratoconus cases: a prospective single-arm study.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Short-term retinal microvascular and structural changes after epi-on and epi-off corneal cross-linking assessed by SD-OCTA.International ophthalmology · 2026Article
- Anti-inflammatory and dry eye benefits of accelerated epi-off corneal cross-linking in pediatric keratoconus with allergic ocular surface disease and elevated MMP-9.Eye and vision (London, England) · 2026Article
- Comparison of t-PTK + CXL and CXL with mechanical debridement for keratoconus: fellow eye study.International ophthalmology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to evaluate the effects of epithelial-off corneal cross-linking (CXL) on the ocular surface and corneal topographic and optical parameters in progressive keratoconus (KCN) cases. STUDY
designProspective single-arm interventional study.
methodsThirty eyes of 25 progressive KCN cases needing corneal CXL entered the study. All the included eyes underwent an epi-off corneal CXl procedure following the Dresden protocol. The ocular surface parameters, including tear break-up time (TBUT), Schirmer I test, and Ocular surface disease index (OSDI), were evaluated at baseline, one and 6 months after the procedure. The corneal imaging with Pentacam (Oculus Inc.) was conducted at these visits, measuring topographic parameters (e.g., K
resultsThe median age of the patients was 24.0 (IQR:21.0-26.5) with a baseline BCVA of 0.045 LogMAR (IQR:0.000-0.301). The BCVA had no significant change in the last follow-up (p:1.000). The baseline median values for TBUT, Schirmer test, and OSDI were 11.0s, 13.0mm, and 28.12, demonstrating a significant ocular surface malfunction. These ocular surface parameters showed no significant change 6 months after CXL (p: 0.662, 0.534, and 0.372, respectively). The K
conclusionProgressive KCN cases cope with some ocular surface problems, such as dry eye, but the corneal CXL is safe for these cases without causing any deterioration in the ocular surface problems. The corneal CXL might not improve the topographic indices and corneal aberrations 6 months after the procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.