ArticleBMC pulmonary medicine2025
Prevalence of chronic obstructive pulmonary disease in high-risk populations at low, intermediate, high altitudes: a population based cross-sectional study in Yunnan Province, China.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Friend or foe: Face masks in patients with COPD at high altitude.Physiological reports · 2026Review
- The prevalence of chronic obstructive pulmonary disease in high-altitude areas of China: a systematic review and meta-analysis.Journal of thoracic disease · 2025Article
- DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases.Human genomics · 2025Review
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Authors and funding
13 authors.
Funding
Abstract
backgroundChronic obstructive pulmonary disease (COPD) represents a significant public health challenge. This study aimed to investigate the epidemiological characteristics of COPD across different altitudes and evaluate the potential influence of altitude on its prevalence of high-risk populations.
methodsThis cross-sectional study employed a multi-stage randomized cluster sampling method and enrolled 11,095 adult residents aged ≥ 20 years at different elevations in Yunnan Province, China. Screening questionnaires identified high-risk individuals among participants, who then underwent pulmonary function tests. COPD was diagnosed based on post-bronchodilator test results. We utilized multivariate logistic regression models to examine the association between altitudes and COPD prevalence while controlling for demographic variables, lifestyle factors, and disease characteristics.
resultsA total of 2,252 (20.3%) were in the high-risk group. The prevalence of COPD in high-risk populations increased with age across low, intermediate, and high altitude areas. COPD patients in high-risk populations at high-altitude areas had a higher prevalence of ethnic minorities and significant biomass fuel exposure. Conversely, the proportion of COPD patients in the severe stages (GOLD III-IV) was notably lower in high-altitude regions. Logistic regression models revealed COPD prevalence in high-risk populations at high altitudes to be significantly lower than at low altitudes, with odds ratios of 0.538(95% CI: 0.343-0.844), 0.470(95% CI: 0.289-0.766), and 0.518 (95% CI: 0.316-0.848) for Models 1, 2, and 3, respectively (all P < 0.05).
conclusionThe prevalence of COPD in high-risk populations is the lowest in the high-altitude regions of Yunnan Province, and high altitude is an independent factor negatively associated with COPD.
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