SynthesisBMC endocrine disorders2025
Prevalence of subclinical hypothyroidism in polycystic ovary syndrome and its impact on insulin resistance: a systematic review and meta-analysis.
Synthesis in BMC endocrine disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of insulin resistance in the adult population: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- First-trimester free thyroxine as an independent predictor of gestational diabetes mellitus: a retrospective cohort study.Advances in laboratory medicine · 2026Article
- FT3 combined with the TyG index for risk stratification of mild cognitive impairment in euthyroid patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
- Verification of reference intervals for routine biochemical tests using the reflimR in Turkish adults.PloS one · 2026Article
- Chronic inflammatory activity in women with normogonadotropic anovulation complicated by subclinical thyroid dysfunction: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Correlation between subclinical hypothyroidism and menstrual irregularities in reproductive-age women.Bioinformation · 2026Article
- Van Wyk-Grumbach Syndrome With Insulin Resistance in Children: A Case Report.Clinical case reports · 2025Article
- Thyroid dysfunction in heart failure with preserved ejection fraction: A systematic review and meta-analysis.ARYA atherosclerosis · 2025Review
- Elevated thyroid-stimulating hormone correlates with insulin resistance and β-cell dysfunction in type 2 diabetes with subclinical hypothyroidism.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough recent studies indicate a high prevalence of subclinical hypothyroidism (SCH) in women with polycystic ovary syndrome (PCOS), the reported prevalence rates vary widely. Therefore, we conducted this study to estimate the pooled prevalence of SCH among women with PCOS. Additionally, emerging evidence suggests that SCH may negatively impact insulin resistance in PCOS. Thus, we examined its effect on insulin resistance indices as our secondary objective.
methodsWe searched PubMed, Web of Science, Scopus, and Embase from their inception to February 25, 2024. Observational studies reporting the prevalence of SCH among women with PCOS were included. Joanna Briggs Institute's (JBI) critical appraisal checklist for prevalence studies was adopted for the risk of bias assessment. The random-effects model was employed to estimate the pooled prevalence with its 95% confidence intervals (CI). The weighted mean difference (WMD) was used to compare the insulin resistance indices between PCOS patients with and without SCH.
resultsTwenty-nine studies comprising 5765 women with PCOS were included. The meta-analysis demonstrated that 19.7% (95% CI: 16.1%; 23.5%) of women with PCOS have SCH. PCOS patients with SCH had significantly higher HOMA-IR (WMD = 0.78, 95% CI: 0.34; 1.22) and fasting insulin (WMD = 2.38, 95% CI: 0.34; 4.42) levels than those without SCH. Differences in fasting plasma glucose and 2-hour postprandial glucose did not reach statistical significance.
conclusionThis systematic review and meta-analysis found that approximately 20% of women with PCOS have SCH. This underscores the need for regular thyroid function testing in these patients. The prevalence of SCH is influenced by the TSH cut-off used for diagnosis, highlighting the need for establishing a standardized TSH cut-off value. Furthermore, SCH significantly elevates the HOMA-IR index and fasting insulin levels, highlighting its potential impact on insulin resistance. Whether these metabolic changes are clinically important and put these individuals at higher risk of developing type 2 diabetes mellitus and cardiovascular disease requires further investigation. SYSTEMATIC REVIEW REGISTRATION NUMBER IN PROSPERO: CRD42024510798. CLINICAL TRIAL NUMBER: Not applicable.
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