ArticleBrain and behavior2025
The Relationship Between Grip Strength and Cognitive Impairment: Evidence From NHANES 2011-2014.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Estimated Cardiorespiratory Fitness and Grip Strength: Independent and Combined Associations With Multimorbidity Risk and Patterns in a Large-Scale Prospective Cohort Study.Journal of the American Heart Association · 2025Article
- The Longitudinal Relationship Between Physical Functions and Cognitive Functions Among Middle-Aged and Older Adults in Primary Care.International journal of environmental research and public health · 2025Article
- Muscle strength, EEG biomarkers, and working memory as interacting predictors of cognitive function in cognitively impaired older adults.Frontiers in aging neuroscience · 2025Article
- Machine learning-based risk prediction model for cognitive dysfunction in elderly individuals.PloS one · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundPrior research has consistently shown an association between muscle strength and various metabolic diseases. However, the relationship between muscle strength and cognitive impairment remains elusive.
methodsUsing data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES), we investigated the association between muscle strength and cognitive impairment. We used multivariate logistic regression, restricted cubic spline regression (RCS), and threshold effects to investigate the impact of muscle strength on cognitive function. In addition, we analyzed the correlation between muscle strength and cognitive impairment in subgroups of age, gender, race, education, smoking status, drinking status, hypertension, diabetes, and heart disease.
results2124 participants were ultimately included for further analysis. Multivariate logistic regression, trend testing, and RCS analysis showed a non-linear negative correlation between muscle strength and cognitive impairment. Threshold effect analysis suggests that when muscle strength reaches a certain value, this relationship undergoes significant changes. In the three cognitive function scoring tests, interaction was only observed in the racial subgroup.
conclusionThis study suggests a negative correlation between muscle strength and cognitive function, which may have a threshold effect. Further longitudinal studies are needed to elucidate its potential mechanisms.
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