ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Rising pressure to understand the risks of hypertension in children with narcolepsy type 1.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Effects of High- Versus Low-Sodium Oxybate on Blood Pressure in Patients With Narcolepsy.Hypertension (Dallas, Tex. : 1979) · 2025Trial
- Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics.European journal of medical research · 2025Article
- When a trail leads to a highway: enhancing the understanding of hypertension in pediatric type 1 narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesMost children/adolescents with narcolepsy type 1 (NT1) are treated with stimulants or modafinil, yet the cardiovascular effects of these medications have not been investigated in this population. We compared vital signs in youth with NT1 before and after exposure to stimulants/modafinil to test the hypotheses that these medications increase rates of elevated blood pressure (BP) and hypertension and that body mass index influences these outcomes.
methodsIn this retrospective study, we collected electronic medical data including vital signs and polysomnography/Multiple Sleep Latency Test results from 39 youth with NT1 aged 7-18 at 3 points over a 20-month period: baseline (drug-naïve/weaned), after initiating treatment, and after treatment optimization. We performed stepwise regression to determine predictors of baseline elevated BP/hypertension. We used McNemar's test and generalized estimating equations to assess the effects of stimulant/modafinil exposure on vital signs.
resultsThe prevalence of elevated BP/hypertension at baseline was 51% in our cohort and increased 21% from baseline to the final visit (
conclusionsYouth with NT1 are at risk for elevated BP/hypertension, particularly after stimulant/modafinil treatment. We recommend revising clinical guidelines to address this risk and advocate for controlled studies to better understand the cardiovascular risks and implications of these treatments in pediatric NT1. CITATION: Montesano E, Garcia ME, Lyon S, et al. Rising pressure to understand the risks of hypertension in children with narcolepsy type 1.
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