Observational studyCurrent medical imaging2025
Evaluation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer through Shear-Wave Elastography.
Observational study in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere remains a lack of methods to accurately assess the efficacy of neoadjuvant chemoradiotherapy for locally advanced rectal cancer.
objectiveThis study aimed to investigate the value of shear-wave elastography in evaluating the treatment response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. MATERIALS AND
methodsThis prospective observational study enrolled 275 patients with locally advanced rectal cancer who received neoadjuvant chemoradiotherapy during September 2021–March 2023. All patients underwent endorectal ultrasound and shear-wave elastography examination before total mesorectal excision. Clinical baseline data, endorectal ultrasound, and shear-wave elastography examination data were collected from all patients. The independent predictors of complete response were analyzed and screened, followed by the establishment of a logistic regression model. The diagnostic efficacy of the model was compared with that of radiologists.
resultsThe results of binary multivariate logistic regression suggested that the mean elastography value of the tumor lesion acted as an independent predictor for the diagnosis of complete response [OR: 0.894 (0.816, 0.981)]. The optimal cutoff value was 14.6 kPa. The area under the receiver operating characteristic curve of the model for predicting complete response in the training and test cohorts was 0.850 and 0.824, respectively. The diagnostic accuracy of the model was significantly higher than that of radiologists (P < 0.001).
conclusionShear-wave elastography can be used as a feasible method to evaluate the complete response of locally advanced rectal cancer after neoadjuvant chemoradiotherapy.
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