Evidence map›Paper›PMID 40103784›Full record

ArticleOsteoarthritis and cartilage open2025

Patients with unilateral patellofemoral pain have altered bone turnover in the painful knee compared to the pain-free knee at rest and after acute knee loading.

Rudi Hansen, Bryan Haddock, René B Svensson, Markus Nowak Lonsdale, Lisbeth Marner, Lene Rørdam, Inge Lise Rasmussen, Christoffer Brushøj, S Peter Magnusson, Marius Henriksen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rudi HansenDepartment of Physical and Occupational Therapy, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Bryan HaddockDepartment of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Denmark.
René B SvenssonInstitute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Markus Nowak LonsdaleDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Lisbeth MarnerDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Lene RørdamDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Inge Lise RasmussenDepartment of Clinical Physiology & Nuclear Medicine, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Christoffer BrushøjInstitute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
S Peter MagnussonDepartment of Physical and Occupational Therapy, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Marius HenriksenThe Parker Institute, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.
Christian CouppéDepartment of Physical and Occupational Therapy, Copenhagen University Hospital Bispebjerg Frederiksberg, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The objective of this study was to investigate subchondral bone turnover at rest and after acute loading using Fluorine-18-labeled sodium fluoride (Na[ Design: Twenty-seven patients with unilateral PFP were recruited from the Institute of Sports Medicine Copenhagen. Participants underwent Na[ Results: At rest, the painful knees showed lower SUV Conclusion: Patella displayed decreased bone metabolism at rest and reduced response to loading in the painful versus pain-free knees. Trochlea in the painful knees showed significantly larger increases in subchondral bone metabolism following knee loading compared to the pain-free knees. These novel findings highlight potential differences in bone turnover between the patellar and trochlear regions.

Indexed as

Bone metabolismBone perfusionBone turnoverNa[18F]FPatellofemoral painPFPPositron Emission Tomography

Identifiers

PMID40103784
PMCPMC11915147

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.