Evidence map›Paper›PMID 40104049›Full record

ArticleiScience2025

tRF-Val-TAC-004 protects against renal ischemia-reperfusion injury via attenuating Apaf1-mediated apoptosis.

Ni Yin, Xian Xie, Dan Li, Shikun Yang, Yan Liu, Yongzhong Tang, Hao Zhang, Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ni YinDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Xian XieDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Dan LiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Shikun YangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Yan LiuDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Yongzhong TangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Hao ZhangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
Wei ZhangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

tRNA-derived fragments (tRFs) play critical roles in cellular process, and we have previously reported that tRFs are involved in ischemia reperfusion injury induced acute kidney injury (IRI-AKI). However, the precise involvement of tRFs in IRI-AKI remains obscure. This study aims to elucidate the impact of tRF-Val-TAC-004 (tRF-Val) on IRI-AKI and uncover the underlying mechanisms. Our observations reveal a significant downregulation of tRF-Val in IRI-AKI mice and its overexpression mitigated renal dysfunction, morphological damage, and apoptosis in IRI-AKI mice, while its inhibition exacerbated these effects. Similar outcomes were replicated in CoCl

Indexed as

Cell biologyMolecular biology

Identifiers

PMID40104049
PMCPMC11914182

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.