Evidence map›Paper›PMID 40104280›Full record

ArticleInfection and drug resistance2025

The Impact of Non-Thyroidal Illness Syndromes on The Prognosis and Immune Profile in Severe Fever with Thrombocytopenia Syndrome Patients.

Hongxiao Wu, Yameng Mu, Yuanni Liu, Ruihua Zhang, Yanli Xu, Yuanyuan Zhang, Chenxi Zhao, Wei Zhang, Ling Lin, Zhihai Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongxiao Wu *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.ORCID 0000-0003-4425-7214
Yameng Mu *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Yuanni LiuDepartment of Infectious Diseases, Yantai Qishan Hospital, Yantai, People's Republic of China.
Ruihua ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Yanli XuDepartment of Infectious Diseases, Yantai Qishan Hospital, Yantai, People's Republic of China.
Yuanyuan ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Chenxi ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Wei ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.
Ling LinDepartment of Infectious Diseases, Yantai Qishan Hospital, Yantai, People's Republic of China.
Zhihai ChenNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China.ORCID 0000-0001-6481-4781

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-thyroidal illness syndrome (NTIS) is the most common endocrine dysfunction in critically ill patients and is often associated with poor prognosis. Thyroid dysfunction and immune cell disturbances are frequently observed in patients with severe fever with thrombocytopenia syndrome (SFTS). This study aims to evaluate the impact of NTIS on the prognosis of SFTS patients and to explore the relationship between thyroid hormones (THs) and immune cell profiles. Methods: Adult patients admitted to Yantai Qishan Hospital for SFTS from January 2023 to December 2023 with no prior history of thyroid disease were retrospectively recruited. Multivariable regressions were used to assess the associations between NTIS and clinical outcomes. Spearman correlation analysis was conducted to evaluate the relationships between immune cells and THs. SFTS patients with NTIS were categorized into four subtypes based on different levels of FT4 and TSH, and the association between NTIS subtypes and mortality was further analyzed. Results: Of the 84 SFTS patients included in the study, 62 (73.8%) were diagnosed with NTIS. Independent risk predictors which may affect prognosis of SFTS patients include NTIS subtype ( Conclusion: NTIS is common in SFTS patients, and SFTS patients with NTIS have a lower survival rate compared to euthyroid patients. The mortality risk in NTIS type 3 patients is higher than in those with NTIS type 1.

Indexed as

immune cellsnon-thyroidal illness syndromeSFTSthyroid dysfunction

Identifiers

PMID40104280
PMCPMC11914451

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.