Evidence map›Paper›PMID 40104404›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2025

Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function.

Kane E Collins, Edmund Gilbert, Vincent Mauduit, Katherine A Benson, Elhussein A E Elhassan, Conall O'Seaghdha, Claire Hill, Amy Jayne McKnight, Alexander P Maxwell, Peter J van der Most and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Kane E CollinsSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Edmund GilbertSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Vincent MauduitEcole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes University, Nantes, France.
Katherine A BensonSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Elhussein A E ElhassanDepartment of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.
Conall O'SeaghdhaDepartment of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.
Claire HillCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Amy Jayne McKnightCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Alexander P MaxwellCentre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Peter J van der MostDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Martin H de BorstDepartment of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Weihua GuanDivision of Biostatistics and Health Data Science, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Pamala A JacobsonCollege of Pharmacy, University of Minnesota, Minneapolis, MN, United States.
Ajay K IsraniInternal Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Brendan J KeatingDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Graham M LordSchool of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Salla MarkkinenFinnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland.
Ilkka HelanteräHelsinki University Hospital, Transplantation and Liver Surgery, Helsinki, Finland.
Kati HyvärinenFinnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland.
Jukka PartanenFinnish Red Cross Blood Service, Research and Development, Biomedicum 1, Helsinki, Finland.
Stephen F MaddenData Science Centre, Beaux Lane House, Royal College of Surgeons in Ireland, Dublin, Ireland.
Matthew B LanktreeDivision of Nephrology, Departments of Medicine and Health Research Methodology, Evidence and Impact, St. Joseph's Healthcare Hamilton, McMaster University and Population Health Research Institute, Hamilton, ON, Canada.
Sophie LimouEcole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR1064, Nantes University, Nantes, France.
Gianpiero L Cavalleri *School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Peter J Conlon *Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.

Funding

Pharmacogenomics of Immune Suppressants in Kidney TransplantationU19AI070119 · NIAID · UNIVERSITY OF MINNESOTA · PI MATAS, ARTHUR J · 2006 to 2016
$17.1M
Long-term Deterioration of Kidney Allograft FunctionU01AI058013 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MATAS, ARTHUR J · 2005 to 2010
$10.2M
Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant RecipientsK01AI130409 · NIAID · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI DORR, CASEY R · 2018 to 2022
$724k
NIAID NIH HHS K01 AI130409NIAID NIH HHS U01 AI058013NIAID NIH HHS U19 AI070119Wellcome Trust
6 · The paper itself

Abstract

Kidney transplant outcomes are influenced by donor and recipient age, sex, HLA mismatch, donor type, anti-rejection medication adherence and disease recurrence, but variability in transplant outcomes remains unexplained. We hypothesise that donor and recipient polygenic burden for traits related to kidney function may also influence graft function. We assembled a cohort of 6,060 living and deceased kidney donor-recipient pairs. We calculated polygenic risk scores (PRSs) for kidney function-related traits in both donors and recipients. We investigated the association between these PRSs and recipient eGFR at 1- and 5-year post-transplant as well as graft failure. Donor: hypertension PRS (

Indexed as

Kidney TransplantationMultifactorial InheritanceAdultAgedFemaleGenetic Risk ScoreGlomerular Filtration RateGraft RejectionGraft SurvivalHumansHypertensionMaleMiddle AgedRisk FactorsTissue DonorsTransplant RecipientseGFRgraft functiongraft survivalmultivariable modelspolygenic risk scores

Identifiers

PMID40104404
PMCPMC11913612

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.