Evidence map›Paper›PMID 40104585›Full record

ArticleKidney diseases (Basel, Switzerland)

Association of Cumulative Remnant Cholesterol with Kidney Function Decline in Chinese Population: A Prospective Cohort Study.

Lei Liu, Changfa Wang, Zhongyang Hu, Pingting Yang, Ying Li, Yufu Zhou, Saiqi Yang, Kui Chen, Shuwen Deng, Xiaoling Zhu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lei LiuHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Changfa WangGeneral Surgery Department, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhongyang HuDepartment of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China.
Pingting YangHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Ying LiHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Yufu ZhouGeneral Surgery Department, The Third Xiangya Hospital, Central South University, Changsha, China.
Saiqi YangHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Kui ChenHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Shuwen DengHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiaoling ZhuHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Xuelian LiuHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.
Yaqin WangHealth Management Medical Center, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: There were limited data regarding the association between remnant cholesterol (RC), an emerging novel lipid marker, and chronic kidney disease (CKD). This study aimed to investigate the association of baseline and cumulative exposure of RC (cumRC) with kidney function decline (KFD) risk in the general population of China. Methods: Using data from the physical examination database in the Third Xiangya Hospital of Central South University (Changsha, China), 22,702 participants (age ≥18 years) without KFD, who underwent 3 consecutive annual health examinations between 2012 and 2015, were included. KFD was recorded during the interval between the third examination and the end of follow-up through 2020. Results: The cumRC was classified into 4 groups according to these cutoff values: 0.92, 1.33, and 1.99 (mmol/L). During a median follow-up of 3.17 years, 1,085 new KFD events were confirmed. Participants in the highest quartile of cumRC had 43% higher risk of KFD (hazard ratio, 1.43 [95% confidence interval, 1.16-1.77]), compared with the lowest quartile. Similarly, restricted cubic spline analysis showed a significant dose-response relationship between cumRC and the risk of KFD (P nonlinearity = 0.0314). However, baseline RC did not show any typical dose-dependent positive relationship with KFD development. In the discordance analysis, high baseline RC/low baseline low-density lipoprotein cholesterol (LDL-C) or high cumRC/low cumLDL-C were all associated with KFD in adjusted models. Conclusion: These data suggest a significant association between cumRC and risk of KFD independent of traditional CVD risk factors as well as the LDL-C level. Therefore, consistent RC monitoring should be given to individuals for early KFD prevention, especially in population with normal LDL-C levels who are often overlooked.

Indexed as

Cohort studyCumulative exposureKidney function declineProspectiveRemnant cholesterol

Identifiers

PMID40104585
PMCPMC11919314

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.