Evidence map›Paper›PMID 40104791›Full record

ArticleACS medicinal chemistry letters2025

Peripherally Restricted Fused Heterocyclic Peptidomimetic Multifunctional Opioid Agonists as Novel, Potent Analgesics.

Haylee R Hammond, Prakash Chaudhari, Ashley Bunnell, Khadija Nefzi, Chongguang Chen, Pingwei Zhao, Shainnel O Eans, Sabrina R Masood, Colette T Dooley, Lee-Yuan Liu-Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haylee R HammondDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Prakash ChaudhariDepartment of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Center for Translational Science, Port Saint Lucie, Florida 34987, United States.
Ashley BunnellDepartment of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Center for Translational Science, Port Saint Lucie, Florida 34987, United States.
Khadija NefziDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Chongguang ChenCenter for Substance Abuse Research and Biochemical Pharmacology Core, Lewis Katz School of Medicine, Temple University, 3500 N. Broad Street, Eighth Floor, Philadelphia, Pennsylvania 19140, United States.
Pingwei ZhaoCenter for Substance Abuse Research and Biochemical Pharmacology Core, Lewis Katz School of Medicine, Temple University, 3500 N. Broad Street, Eighth Floor, Philadelphia, Pennsylvania 19140, United States.
Shainnel O EansDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Sabrina R MasoodDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Colette T DooleyTechnical Writer-Editor-Reviewer, Vero Beach, Florida 32960United States.
Lee-Yuan Liu-ChenCenter for Substance Abuse Research and Biochemical Pharmacology Core, Lewis Katz School of Medicine, Temple University, 3500 N. Broad Street, Eighth Floor, Philadelphia, Pennsylvania 19140, United States.
Jay P McLaughlinDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Adel NefziDepartment of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Center for Translational Science, Port Saint Lucie, Florida 34987, United States.ORCID https://orcid.org/0000-0003-0155-5887

Funding

Synthesis and in vitro and in vivo screening of fused and tethered heterocyclic peptidomimetics for the discovery of new analgesics with decreased side effectsR33DA044425 · NIDA · TORREY PINES INST FOR MOLECULAR STUDIES · PI MCLAUGHLIN, JAY P., NEFZI, ADEL · 2020 to 2022
$922k
NIDA NIH HHS R33 DA044425
6 · The paper itself

Abstract

Heterocyclic peptidomimetics are constrained compounds that mimic the biological efficacy of peptides while offering increased stability. We have previously generated a diazaheterocyclic peripherally selective, mixed-opioid agonist peptidomimetic that produced synergistic antinociception with decreased side effects. Working from two earlier templates, we report here the synthesis of 15 new diazaheterocyclic analogues. In vitro screening with radioligand competition binding assays and [

Identifiers

PMID40104791
PMCPMC11912268

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.