Evidence map›Paper›PMID 40104806›Full record

ArticleACS medicinal chemistry letters2025

Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity.

Fatima-Zahra Ishmail, Dina Coertzen, Sizwe Tshabalala, Meta Leshabane, Shante da Rocha, Mathew Njoroge, Liezl Gibhard, Lyn-Marie Birkholtz, John G Woodland, Timothy J Egan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatima-Zahra IshmailDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Dina CoertzenDepartment of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
Sizwe TshabalalaDepartment of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
Meta LeshabaneDepartment of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
Shante da RochaDepartment of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
Mathew NjorogeHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0003-1276-2224
Liezl GibhardHolistic Drug Discovery and Development (H3D) Centre, University of Cape Town, Rondebosch 7701, South Africa.
Lyn-Marie BirkholtzDepartment of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield 0028, South Africa.
John G WoodlandDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-6273-5596
Timothy J EganDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-7720-8473
Kathryn J WichtDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-6145-9956
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0002-1327-4727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed-ligand platinum(II) complexes incorporating bipyridine and acyl-thiourea ligands were synthesized and evaluated for their

Identifiers

PMID40104806
PMCPMC11912270

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.