Evidence map›Paper›PMID 40105007›Full record

ArticleBioscience reports2025

Development and validation of an epigenetic signature of allostatic load.

Jonviea D Chamberlain, Daniel Ackermann, Murielle Bochud, Tom Booth, Laurence Chapatte, Janie Corley, Simon R Cox, Sarah E Harris, Cassandre Kinnaer, Robert-Paul Juster and 9 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jonviea D ChamberlainDepartment of Epidemiology and Health Systems (DESS), Unisanté, University Center for Primary Care and Public Health, Lausanne, Switzerland.ORCID 0000-0002-9515-1076
Daniel AckermannDepartment for Nephrology and Hypertension Inselspital, Inselspital, Bern University Hospital and University of Bern, Bern 3010, Switzerland.
Murielle BochudDepartment of Epidemiology and Health Systems (DESS), Unisanté, University Center for Primary Care and Public Health, Lausanne, Switzerland.
Tom BoothLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Laurence ChapatteGenknowme, Epalinges, Switzerland.
Janie CorleyLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Cassandre KinnaerGenknowme, Epalinges, Switzerland.
Robert-Paul JusterDepartment of Psychology, University of Montreal, Montreal, Quebec, Canada.
Isabella LocatelliDepartment of Epidemiology and Health Systems (DESS), Unisanté, University Center for Primary Care and Public Health, Lausanne, Switzerland.
David NanchenDepartment of Health Promotion and Prevention (DPSP), Unisanté, University Center for Primary Care and Public Health, Lausanne, Switzerland.
Belène PonteDepartment of Nephrology and Hypertension, Geneva University Hospitals, Geneva, Switzerland.
Menno PruijmService of Nephrology and Hypertension, University Hospital of Lausanne, and University of Lausanne, Lausanne 1011, Switzerland.
Sylvain PradervandVital-IT Group, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Paul G ShielsSchool of Molecular Biosciences, Davidson Building, MVLS, University of Glasgow, Glasgow G12 8QQ, UK.ORCID 0000-0002-7577-9843
Silvia StringhiniDepartment of Epidemiology and Health Systems (DESS), Unisanté, University Center for Primary Care and Public Health, Lausanne, Switzerland.
Sébastien Nusslé *Genknowme, Epalinges, Switzerland.
Semira Gonseth-NussléGenknowme, Epalinges, Switzerland.

Funding

Wellcome Trust
6 · The paper itself

Abstract

The allostatic load (AL) concept measures physiological dysregulation in response to internal and external stressors that accumulate across the life course. AL has been consistently linked to chronic disease risk across studies. However, there is considerable variation in its operationalization. In the present study, DNA methylation (DNAm) data (using the Illumina Infinium MethylationEPIC BeadChip array) from the Swiss Kidney Project on Genes in Hypertension (SKIPOGH) cohort, a Swiss-based family cohort study, were used in a discovery epigenome-wide association study to identify cytosine-guanine nucleotide sites associated with phenotypic measures of AL. Elastic net linear regression models were used to estimate an epigenetic signature of AL (methAL), including an Illumina HumanMethylation450K (HM450K) assay-compatible signature (methALT). The methALT signature was validated in the 1936 Lothian Birth Cohort (LBC1936), population-based prospective cohort study. We found that the methAL signature was positively associated with the clinical phenotype of AL in both the SKIPOGH (R2 = 0.59) and LBC1936 (R2 = 0.16) cohorts. In the validation cohort, a one standard deviation increase in methALT signature was associated with 25% higher odds of reported history of cardiovascular disease (CVD) (odd ratio [OR] = 1.25, 95% confidence interval [CI] = 1.05-1.50), and a nearly two-fold increase in all-cause mortality rate at the beginning of follow-up (hazard ratio = 1.68, 95% CI = 1.33-2.13) when adjusting for all potential confounders. In conclusion, the epigenetic signature for AL not only correlated well with phenotype-based AL scores but also exhibited a stronger association with the history of CVD and all-cause mortality compared with AL scores. The methAL signature could help assuage issues of comparison across studies.

Indexed as

AllostasisDNA MethylationEpigenesis, GeneticAdultAgedFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPhenotypeProspective StudiesSwitzerlandAllostatic loadChronic diseasesChronic StressDNA methylationEpigenetic signaturePrevention

Identifiers

PMID40105007
PMCPMC12203956

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.