Evidence map›Paper›PMID 40105091›Full record

ArticleImmunity, inflammation and disease2025

Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity.

Karina Bingham, Yousef Al Zahrani, Iain Stewart, Michael A Portelli, Andrew Fogarty, Tricia M McKeever, Ananga Singapuri, Liam G Heaney, Adel H Mansur, Rekha Chaudhuri and 12 more

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In one paragraph

Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Karina BinghamCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.ORCID 0000-0003-4844-4113
Yousef Al ZahraniCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.ORCID 0000-0002-7384-5958
Iain StewartFaculty of Medicine, National Heart & Lung Institute Imperial College, London, UK.
Michael A PortelliCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Andrew FogartyDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Tricia M McKeeverDivision of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
Ananga SingapuriInstitute for Lung Health, University of Leicester, Glenfield Hospital, Leicester, UK.
Liam G HeaneyCentre for Infection and Immunity, Queen's University of Belfast, Belfast, UK.
Adel H MansurRespiratory Medicine, Birmingham Heartlands Hospital, Birmingham, UK.
Rekha ChaudhuriInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Neil C ThomsonInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
John W HollowayNIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.ORCID 0000-0001-9998-0464
Peter H HowarthNIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.ORCID 0000-0003-0619-7927
Ratko DjukanovicNIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
John D BlakeyMedical School, Curtin University, Perth, Western, Australia.
Anoop ChauhanResearch and Innovation, Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
Christopher E BrightlingDepartment of Health Sciences, University of Leicester, Leicester, UK.
Zara E K PogsonUnited Lincolnshire Hospitals NHS Trust, Lincoln County Hospital, Lincoln, UK.
Ian P HallCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Luisa Martinez-PomaresSchool of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.
Dominick ShawCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Ian SayersCentre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK.

Funding

This research was supported by the NIHR Nottingham Biomedical Centre, University of Nottingham.Wellcome Trust 225221
6 · The paper itself

Abstract

backgroundAsthma is a heterogeneous disease characterized by overlapping clinical and inflammatory features.

objectiveThis study aimed to provide insight into the systemic inflammatory profile in asthma, greater understanding of asthma endotypes and the contribution of genetic risk factors to both.

methods4205 patients with asthma aged 16-60 were recruited from UK centers; serum cytokines were quantified from 708, including cytokines associated with Type 1, 2 and 17 inflammation. 3037 patients were genotyped for 25 single nucleotide polymorphisms associated with moderate-severe asthma.

resultsSerum cytokines associated with Th2 inflammation showed high coordinated expression for example, IL-4/IL-5 (R

conclusionSystemic inflammation in asthma is complex. Patients had multiple overlapping inflammatory profiles suggesting several disease mechanisms. Genetic risk factors for moderate-severe asthma confirmed previous associations with childhood onset of asthma.

Indexed as

AsthmaCytokinesAdolescentAdultFemaleGenetic Predisposition to DiseaseGenotypeHumansImmunoglobulin EMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsTh2 CellsYoung AdultCytokinesImmunoglobulin Easthmablood cytokinesendotypesgenetics

Identifiers

PMID40105091
PMCPMC11920881

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.