ArticleJournal of veterinary internal medicine
Accuracy of the Freestyle Libre 3 Continuous Glucose Monitoring System in Hypo- and Euglycemic Cats.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- iCatCare 2025 consensus guidelines on the diagnosis and management of diabetes mellitus in cats.Journal of feline medicine and surgery · 2025Guideline
- Evaluating the correlation between serum fructosamine concentration and interstitial glucose concentration in cats with diabetes mellitus.Journal of veterinary internal medicine · 2026Article
- Erratum for "Accuracy of the Freestyle Libre 3 Continuous Glucose Monitoring System in Hypo- and Euglycemic Cats".Journal of veterinary internal medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe FreeStyle Libre 3 (FSL3) has several improvements compared to previous FreeStyle Libre systems, but its accuracy has not yet been determined in cats. In diabetic people, FSL3 offers increased accuracy, and its smaller size could be advantageous for use in veterinary patients.
objectivesAssess the accuracy of FSL3 in cats with experimentally induced hypoglycemia. ANIMALS: Seven healthy, purpose-bred cats.
methodsHyperinsulinemic-hypoglycemic clamps were performed. Interstitial glucose concentration (IG), measured by FSL3, was compared to blood glucose concentration (BG) measured by AlphaTrak2. Data were analyzed for all paired measurements (n = 474) and during stable BG (≤ 1 mg/dL/min change over 10 min). Pearson's r test, Bland-Altman test, and Parkes Error Grid analysis (EGA) respectively used to determine correlation, bias, and clinical accuracy.
resultsBlood glucose concentration and IG correlated strongly (r = 0.86, p < 0.0001) in stable glycemia and moderately at all rates of change (r = 0.73, p < 0.0001). Analytical accuracy was not achieved, whereas clinical accuracy was demonstrated with 99%-100% of the results in zones A + B of the Parkes EGA. Interstitial glucose concentration underestimated BG in euglycemia and mild hypoglycemia (mean -11.7 ± 11.2, -5.5 ± 9.1, -1.5 ± 6.0 mg/dL in the ranges 91-120, 66-90, and 56-65 mg/dL, respectively), but overestimated BG in marked hypoglycemia (mean 6.3 ± 5.7, 15.7 ± 5.6 mg/dL in the ranges 46-55 and < 45 mg/dL, respectively).
conclusionsThe FSL3 underestimates BG across most of the hypo-euglycemic range but overestimates BG in marked hypoglycemia (< 55 mg/dL). Recognizing the proportional, glycemic-dependent bias of FSL3 improves the safety of its clinical application in cats.
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