ArticleRevista da Associacao Medica Brasileira (1992)2025
Association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus and evaluation of statin treatment effects.
Article in Revista da Associacao Medica Brasileira (1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiovascular outcomes and adverse drug reactions associated with the use of ezetimibe in combination with a statin in diabetes mellitus patients with higher risk for myocardial infarction: a meta-analysis.BMC cardiovascular disorders · 2026 · on this mapPooled it
- Comment on "Association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus and evaluation of statin treatment effects".Revista da Associacao Medica Brasileira (1992) · 2025Article
- Comments: "Association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus and evaluation of statin treatment effects".Revista da Associacao Medica Brasileira (1992) · 2025Article
- Comment on "Association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus and evaluation of statin treatment effects".Revista da Associacao Medica Brasileira (1992) · 2025Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus patients and evaluate the effectiveness of statin therapy.
methodsThis retrospective analysis included 120 patients diagnosed with type 2 diabetes mellitus. Of these, 90 patients diagnosed with coronary heart disease via coronary angiography received rosuvastatin treatment for over 6 months. The remaining 30 patients exhibited no coronary heart disease or other diabetic macrovascular complications and had not received any lipid-lowering treatment. Patients with type 2 diabetes mellitus and coronary heart disease were categorized into two groups based on the severity of coronary lesions. Baseline characteristics and blood lipid data were compared among groups. Logistic regression analysis was employed to investigate the association between lipoprotein(a) and coronary heart disease risk in type 2 diabetes mellitus patients. Receiver operating characteristic curves were utilized to evaluate the diagnostic value of lipoprotein(a) for coronary heart disease.
resultsCompared with the control group, lipoprotein(a) levers were higher in both the mild and severe groups. Logistic regression analysis demonstrated that lipoprotein(a) is independently associated with the risk of coronary heart disease in type 2 diabetes mellitus patients. The area under the receiver operating characteristic curve for lipoprotein(a) was 0.729. When lipoprotein(a) was 97.5 mg/L, the diagnosis of coronary heart disease had high sensitivity and specificity. After statin therapy, high-density lipoprotein cholesterol and apolipoprotein A levels increased, while other lipid parameters decreased. However, the lipoprotein(a) level decrease was not statistically significant.
conclusionLipoprotein(a) is an independent risk factor for coronary heart disease in type 2 diabetes mellitus patients. Lipid-lowering therapy with statins alone cannot reduce lipoprotein(a) levels.
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