Evidence map›Paper›PMID 40106140›Full record

ArticleMedical oncology (Northwood, London, England)2025

Pan-cancer analysis unveils the role and mechanisms of neddylation modifications in tumorigenesis.

Qianhua Hu, Xiang Li, Ping Wang, Ying Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Ubiquitin-conjugating Enzymes in Cancer.International journal of biological sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qianhua Hu *Key Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Health Science Center, Hunan Normal University, Changsha, China.ORCID http://orcid.org/0009-0006-0388-9097
Xiang Li *Key Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Health Science Center, Hunan Normal University, Changsha, China.ORCID http://orcid.org/0009-0008-1558-464X
Ping WangKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Health Science Center, Hunan Normal University, Changsha, China.ORCID http://orcid.org/0009-0008-3860-2214
Ying XieKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Health Science Center, Hunan Normal University, Changsha, China. xieying@hunnu.edu.cn.ORCID http://orcid.org/0000-0001-7568-2569

Funding

National Natural Science Foundation of China 82103887National Science Fund for Excellent Young Scholars of Hunan Province 2023JJ20032
6 · The paper itself

Abstract

This study explores the roles of ubiquitin-like modification genes in pan-cancer, focusing on their regulatory mechanisms, prognostic implications, and drug sensitivity. Data on five key neddylation pathway genes (RBX1, NEDD8, NAE1, UBA3, UBE2M) were collected from TCGA and GTEx databases, covering mRNA expression, DNA methylation, SNVs, and CNVs. Gene expression differences between normal and cancer tissues, along with associations with genetic alterations, methylation, and cancer-related pathways, were analyzed. Drug sensitivity correlations were assessed using GDSC and CTRP databases. Neddylation pathway genes exhibit hypomethylation and overexpression across various cancers, correlating with poor prognosis. SNVs are predominantly missense mutations, while CNVs are mostly heterozygous deletions and amplifications. These genes regulate several key cancer-related pathways, such as DNA damage repair, cell cycle modulation, and inhibition of RTK/RAS/MAPK pathways. Ubiquitin-like modification genes are associated with poor prognosis due to their low methylation and high expression in cancers. Their genetic alterations impact cancer pathways, underscoring their potential as therapeutic targets and prognostic biomarkers.

Indexed as

CarcinogenesisNEDD8 ProteinNeoplasmsBiomarkers, TumorDNA Copy Number VariationsDNA MethylationGene Expression Regulation, NeoplasticHumansPrognosisBiomarkers, TumorNEDD8 ProteinNEDD8 protein, humanDNA methylationDrug sensitivityGenetic alterationsNeddylation modificationPan-cancer analysisTumorigenesis

Identifiers

PMID40106140

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.