Evidence map›Paper›PMID 40107018›Full record

ReviewRedox biology2025

Thiosulphate sulfurtransferase: Biological roles and therapeutic potential.

Yang Luo, Shaden Melhem, Martin Feelisch, Laurent Chatre, Nicholas M Morton, Amalia M Dolga, Harry van Goor

Abstract readReview
In one paragraph

Review in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Catechol-Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. HFrontiers in cell and developmental biology · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yang LuoUniversity of Groningen, Dept. of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, Groningen, the Netherlands; University Medical Center Groningen, Dept. of Pathology and Medical Biology, Groningen, the Netherlands.
Shaden MelhemCentre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Martin FeelischClinical and Experimental Sciences, Faculty of Medicine, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Laurent ChatreUniversité de Caen Normandie, CNRS, Normandie Univ, ISTCT, UMR6030, GIP Cyceron, Caen, F-14000, France.
Nicholas M MortonCentre for Systems Health and Integrated Metabolic Research, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Amalia M DolgaUniversity of Groningen, Dept. of Molecular Pharmacology, Groningen Research Institute of Pharmacy, Faculty of Science and Engineering, Groningen, the Netherlands.
Harry van GoorUniversity Medical Center Groningen, Dept. of Pathology and Medical Biology, Groningen, the Netherlands. Electronic address: h.van.goor@umcg.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondria are central to eukaryotic cell function, driving energy production, intermediary metabolism, and cellular homeostasis. Dysregulation of mitochondrial function often results in oxidative stress, a hallmark of numerous diseases, underscoring the critical need for maintaining mitochondrial integrity. Among mitochondrial enzymes, thiosulfate sulfurtransferase (TST) has emerged as a key regulator of sulfur metabolism, redox balance, and Fe-S protein maintenance. Beyond its well-known role in cyanide detoxification, TST facilitates hydrogen sulfide (H

Indexed as

Thiosulfate SulfurtransferaseAnimalsAntioxidantsHumansHydrogen SulfideMitochondriaOxidation-ReductionOxidative StressAntioxidantsHydrogen SulfideThiosulfate SulfurtransferaseMitochondrial dysfunctionOxidative stressRedox signalingThiosulfate sulfurtransferase (TST)

Identifiers

PMID40107018
PMCPMC11957799

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.