Evidence map›Paper›PMID 40107299›Full record

ReviewSeminars in neurology2025

Invasive Neurostimulation for the Treatment of Epilepsy.

Shirin Jamal Omidi, Brian Nils Lundstrom

Abstract readReview
In one paragraph

Review in Seminars in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shirin Jamal OmidiDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Brian Nils LundstromDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.

Funding

Novel Diagnostic Stimulation to Quantify Cortical Excitability and Guide Epilepsy TherapyR01NS129622 · NINDS · MAYO CLINIC ROCHESTER · PI Brian Nils Lundstrom · 2023 to 2026
$1.6M
NINDS NIH HHS R01 NS129622NINDS NIH HHS R01NS129622
6 · The paper itself

Abstract

Although electricity has been used in medicine for thousands of years, bioelectronic medicine for treating epilepsy has become increasingly common in recent years. Invasive neurostimulation centers primarily around three approaches: vagus nerve stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS). These approaches differ by target (e.g., cranial nerve, cortex, or thalamus) and stimulation parameters (e.g., triggered stimulation or continuous stimulation). Although typically noncurative, these approaches can dramatically reduce the seizure burden and offer patients new treatment options. There remains much to be understood about optimal targets and individualized stimulation protocols. Objective markers of seizure burden and biomarkers that quickly quantify neural excitability are still needed. In the future, bioelectronic medicine could become a curative approach that remodels neural networks to reduce pathological activity.

Indexed as

Deep Brain StimulationEpilepsyVagus Nerve StimulationHumans

Identifiers

PMID40107299
PMCPMC12064384

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.