ArticlePharmacology, biochemistry, and behavior2025
Operant effort-based decision-making task reveals sex differences in motivational behavior but no long-term effects of adolescent intermittent ethanol in Sprague Dawley rats.
Article in Pharmacology, biochemistry, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Loss of motivated behavior, or apathy, is a key feature across multiple affective disorders, and is assessed via operant effort-based decision-making (EBDM). The mechanisms of amotivation have been connected to pro-inflammatory signaling which can directly impact dopamine signaling. Chronic alcohol exposure is associated with altered immune signaling and impaired goal-directed behavior, so the present studies assessed the impact of adolescent intermittent ethanol (AIE) on EBDM in adulthood across sex. Adolescent male and female (N = 32/n = 8 per group) Sprague-Dawley rats were exposed to ethanol (4 g/kg) intragastrically on a 3 days on/2 days off schedule during postnatal days ~30-50 or given vehicle, and allowed to age into adulthood (P80+). All rats were then trained on the operant EBDM concurrent FR5/chow task, after which we tested the impact of sex and AIE history on responding 1) during breakpoint challenge raising the FR requirement in a log
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