Evidence map›Paper›PMID 40107516›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2025

Effects of silica nanoparticles with varied physicochemical properties on the survival and functionality of saturated macrophages.

Sushanto Kumar Saha, Cansu Umran Tunc, Nitish Khurana, Jason William Grunberger, Hamidreza Ghandehari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sushanto Kumar SahaUtah Center for Nanomedicine, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
Cansu Umran TuncUtah Center for Nanomedicine, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.
Nitish KhuranaUtah Center for Nanomedicine, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA; Division of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA.
Jason William GrunbergerUtah Center for Nanomedicine, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA.
Hamidreza GhandehariUtah Center for Nanomedicine, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: hamid.ghandehari@pharm.utah.edu.

Funding

BIOLOGICAL FATE AND BIOCOMPATIBILITY OF SILICA-BASED NANOCONSTRUCTSR01ES024681 · NIEHS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Hamid Ghandehari · 2014 to 2026
$4.1M
NIEHS NIH HHS R01 ES024681
6 · The paper itself

Abstract

Silica nanoparticles (SNPs) have shown potential as nanocarriers in diagnostic, imaging, and drug delivery applications. To use SNPs for systemic drug delivery, it is important to have a detailed understanding of how these particles interact with the mononuclear phagocytic system (MPS). Whether or not SNPs may saturate the macrophages, thereby influencing their function and impairing innate immune responses, remains poorly understood. In this work, we defined macrophage saturation using RAW 264.7 macrophages as a model and studied four SNPs with variations in size and porosity. We further explored the downstream effects of SNP uptake by macrophages, including apoptosis/necrosis, cell cycle progression, membrane integrity, and phagocytic activity. The data demonstrate that SNPs do not alter major cellular functions at their respective nontoxic, saturating concentrations.

Indexed as

Drug CarriersMacrophagesNanoparticlesSilicon DioxideAnimalsApoptosisCell CycleCell SurvivalMiceParticle SizePhagocytosisPorosityRAW 264.7 CellsDrug CarriersSilicon DioxideMacrophage saturationNanomedicineNanotoxicologyPhysicochemical propertiesSilica nanoparticles

Identifiers

PMID40107516
PMCPMC12718553

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.