Evidence map›Paper›PMID 40107558›Full record

ArticleInternational journal of biological macromolecules2025

Molecular requirements of chromogranin B for the long-sought anion shunter of regulated secretion.

Gaya P Yadav, Mani Annamalai, D Walker Hagan, Lina Cui, Clayton Mathews, Qiu-Xing Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Gaya P YadavDepartments of Microbiology and Cell Science, and Medicinal Chemistry, University of Florida, Gainesville, FL 32611, USA; Departments of Materials Design and Innovation and HWI, State University of New York at Buffalo, Buffalo, NY 14201, USA; Currently at the Department of Biochemistry & Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, TX 77843, USA.
Mani AnnamalaiDepartment of Pathology, College of Medicine, University of Florida, 1275 Center Drive, Gainesville, FL 32610, USA.
D Walker HaganJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, FL 32610, USA.
Lina CuiDepartment of Medicinal Chemistry, University of Florida, 1275 Center Drive, Gainesville, FL 32611, USA.
Clayton MathewsDepartment of Pathology, College of Medicine, University of Florida, 1275 Center Drive, Gainesville, FL 32610, USA.
Qiu-Xing JiangResearch Unit in Intelligent Utilization of Marine Biomacromolecules and Marine Cryo-EM Center, Laoshan Laboratory, Qingdao, Shandong 266200, China; Departments of Microbiology and Cell Science, and Medicinal Chemistry, University of Florida, Gainesville, FL 32611, USA; Departments of Materials Design and Innovation and HWI, State University of New York at Buffalo, Buffalo, NY 14201, USA; Department of Medicinal Chemistry, University of Florida, 1275 Center Drive, Gainesville, FL 32611, USA; Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA. Electronic address: qiuxingj@buffalo.edu.

Funding

Cell Biology Research Improvements and RenovationsC06RR030414 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI FITZ, JOHN GREGORY · 2010 to 2010
$15.0M
The Southeastern Consortium for Microscopy of MacroMolecular MachinesU24GM116788 · NIGMS · FLORIDA STATE UNIVERSITY · PI AGBANDJE-MCKENNA, MAVIS, BULLITT, ESTHER · 2016 to 2020
$4.6M
Midwest Consortium for High Resolution Cryoelectron MicroscopyU24GM116789 · NIGMS · PURDUE UNIVERSITY · PI BULLITT, ESTHER, DAI, WEI · 2017 to 2021
$3.5M
Molecular Mechanisms of the RNAi/MicroRNA PathwaysR01GM111367 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, QIU-XING, LIU, QINGHUA · 2015 to 2018
$1.4M
Structural study of a Kv channel in different conformations in membranesR01GM093271 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, QIU-XING · 2010 to 2013
$1.2M
Obtaining 3D structures with subnanogram macromoleculesR01GM088745 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, QIU-XING · 2009 to 2012
$1.0M
An 8K camera for the cryoEM at UT Southwestern Medical CenterS10RR027972 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI JIANG, QIU-XING · 2011 to 2011
$600k
Chemically engineered bilayers for cryoEM imaging of membrane proteins in continuous membranesR21GM131231 · NIGMS · UNIVERSITY OF FLORIDA · PI PAZ, AVIV · 2019 to 2020
$476k
NCRR NIH HHS C06 RR030414NCRR NIH HHS S10 RR027972NIGMS NIH HHS R01 GM088745NIGMS NIH HHS R01 GM093271NIGMS NIH HHS R01 GM111367NIGMS NIH HHS R21 GM131231NIGMS NIH HHS U24 GM116788NIGMS NIH HHS U24 GM116789
6 · The paper itself

Abstract

All eukaryotes utilize regulated secretion to release molecular signals packaged in secretory granules for local and remote signaling. An anion shunt conductance was first suggested in secretory granules of bovine chromaffin cells nearly five decades ago. Biochemical identity of this conductance remains undefined. CLC-3, an intracellular Cl

Indexed as

AnionsChromogranin BAnimalsCattleChloride ChannelsChromaffin CellsChromaffin GranulesHydrogen-Ion ConcentrationInsulinInsulin-Secreting CellsInsulin SecretionMiceMice, KnockoutSecretory VesiclesAnionsChloride ChannelsChromogranin BInsulinAnion shunt pathwayCargo maturationDopamine loadingGranule acidificationHyperproinsulinemiaNeurodegenerative diseasesNeuroendocrine cancerProinsulin-to-insulin conversionRegulated secretory pathwaysSecretory granulesType 2 diabetes (T2DM)

Identifiers

PMID40107558
PMCPMC12162349

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.