Evidence map›Paper›PMID 40107673›Full record

ArticleJournal for immunotherapy of cancer2025

ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis.

Shelley Herbrich, Mehdi Chaib, Padmanee Sharma

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shelley HerbrichGenitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-3825-6752
Mehdi ChaibImmunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID http://orcid.org/0000-0002-4793-0120
Padmanee SharmaGenitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA padsharma@mdanderson.org.ORCID http://orcid.org/0000-0003-4658-055X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) remains one of the most aggressive and therapeutically challenging breast cancer subtypes. In their recent study, Cao

Indexed as

Immunotherapy, AdoptiveInducible T-Cell Co-Stimulator ProteinReceptors, Chimeric AntigenT-LymphocytesTriple Negative Breast NeoplasmsAnimalsFemaleHumansMiceNeoplasm MetastasisICOS protein, humanInducible T-Cell Co-Stimulator ProteinReceptors, Chimeric AntigenBreast CancerChimeric antigen receptor - CARImmunotherapy

Identifiers

PMID40107673
PMCPMC11927425

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.