Evidence map›Paper›PMID 40107801›Full record

ReviewHeart failure clinics2025

Immune Dysregulation in Ischemic Heart Disease Among Individuals with Human Immunodeficiency Virus.

Meilynn Shi, Matthew J Feinstein

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heart failure clinics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Meilynn ShiDivision of Cardiology, Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Matthew J FeinsteinDivision of Cardiology, Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: matthewjfeinstein@northwestern.edu.

Funding

Myocardial Vulnerability to Ischemia-Induced Dysfunction and Heart Failure: The Impact of HIV/SIV, ART, and Targeted ImmunotherapyR01HL154862 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FEINSTEIN, MATTHEW JOEL, VASILE PANDREA, IVONA · 2020 to 2023
$3.1M
Immunologic, Inflammatory, and Clinical contributors to HIV-Related Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL156792 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FEINSTEIN, MATTHEW JOEL · 2021 to 2024
$2.9M
NHLBI NIH HHS R01 HL154862NHLBI NIH HHS R01 HL156792
6 · The paper itself

Abstract

Individuals with human immunodeficiency virus (HIV) experience an elevated risk of ischemic heart disease and related cardiovascular sequelae. This is due to a combination of factors including traditional comorbidities, adverse effects of antiretroviral therapy, low-level viremia, viral coinfection, mucosal injury, and chronic immune activation and dysregulation. Understanding the underlying mechanisms, especially as they relate to inflammation, has implications for prevention, diagnostics, and therapeutics. This review highlights some of the foundational and recent literature on clinical phenotypes, diagnostic tools, and promising pharmacotherapies, along with future directions for translational research and clinical implementation.

Indexed as

HIV InfectionsMyocardial IschemiaHumansInflammationHeart failureHIVImmune dysregulationImmune phenotypeInflammationIschemic heart disease

Identifiers

PMID40107801
PMCPMC11960833

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.