Evidence map›Paper›PMID 40108053›Full record

ArticleArchives of microbiology2025

Exploring the multifaceted roles of histone deacetylase inhibitor vorinostat in the cell growth, mycelial morphology, pigments, and citrinin biosynthesis of Monascus purpureus.

Run-Ya Li, Chen-Yu Zhang, Shaoxiang Xiao, Xin-Yi Liu, Ru-Xue Li, Jing Li, Hao Li, Jun Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Run-Ya Li *Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Chen-Yu Zhang *Hunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Shaoxiang Xiao *Hunan Vocational College of Science and Technology, Changsha, 410004, Hunan, China.
Xin-Yi LiuHunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Ru-Xue LiHunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Jing LiHunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Hao LiHunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Jun LiuHunan Key Laboratory of Grain-oil Deep Process and Quality Control, National Engineering Research Center of Rice and Byproduct Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China. liujundandy@csuft.edu.cn.

Funding

National Natural Science Foundation of China No. 32101906the Science and Technology Innovation Program of Hunan Province No. 2022RC1018
6 · The paper itself

Abstract

Acetylation is an important modification type of histones, which is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). In this study, the histone acetylation level of Monascus was enhanced through the exogenous addition of the HDACs inhibitor vorinostat, and the regulation effects of histone acetylation on cell growth and secondary metabolism were evaluated. The results demonstrated that the augmentation of histone acetylation level could slightly facilitate sugar consumption, increase biomass weight, and significantly induce noticeable morphological alterations. Furthermore, in the presence of 80 μmol/L vorinostat concentration, there was a significant reduction observed in both extracellular and intracellular Monascus pigments, citrinin productions, with decreases of 35.46%, 63.90%, and 98.33% respectively. RT-qPCR results showed that adding vorinostat resulted in the up-regulation of HAT genes and down-regulation of HDAC genes. Additionally, transcriptome analysis revealed that glycolysis, tricarboxylic acid cycle, fatty acid metabolism, cell membrane anchor-protein related genes, and biosynthetic pathways involved in ergosterol and chitin synthesis were upregulated. Conversely, the electron transport chain and genetic clusters associated with Monascus pigments and citrinin synthesis were down-regulated. These findings underscore the pivotal role of histone acetylation in regulating the cell growth and secondary metabolism of M. purpureus and extend novel perspectives on the potential applications of clinical compounds derived from this process.

Indexed as

CitrininHistone Deacetylase InhibitorsMonascusMyceliumPigments, BiologicalVorinostatAcetylationFungal ProteinsGene Expression Regulation, FungalHistone AcetyltransferasesHistone DeacetylasesHistonesCitrininFungal ProteinsHistone AcetyltransferasesHistone Deacetylase InhibitorsHistone DeacetylasesHistonesPigments, BiologicalVorinostatCitrininHistone acetylationMonascus pigmentsMorphologyM. purpureusVorinostat

Identifiers

PMID40108053

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.