Evidence map›Paper›PMID 40108256›Full record

Observational studyMolecular psychiatry2025

Generalizability of clinical prediction models in mental health.

Maike Richter, Daniel Emden, Ramona Leenings, Nils R Winter, Rafael Mikolajczyk, Janka Massag, Esther Zwiky, Tiana Borgers, Ronny Redlich, Nikolaos Koutsouleris and 14 more

Abstract readObservational Study
In one paragraph

Observational study in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Maike Richter *Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany. maike.richter@med.uni-jena.de.ORCID http://orcid.org/0000-0003-4078-3954
Daniel Emden *Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Ramona LeeningsDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Nils R WinterInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Rafael MikolajczykGerman Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Germany.
Janka MassagGerman Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Germany.
Esther ZwikyGerman Center for Mental Health (DZPG), Site Jena-Magdeburg-Halle, Germany.ORCID http://orcid.org/0000-0002-6733-8087
Tiana BorgersInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Ronny RedlichInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-7018-4525
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, University Hospital LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-6825-6262
Renata FalgueraDepartment of Psychiatry and Psychotherapy, University Hospital LMU Munich, Munich, Germany.
Sharmili Edwin ThanarajahDepartment for Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Frank PadbergDepartment of Psychiatry and Psychotherapy, University Hospital LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7638-8310
Matthias A ReinhardDepartment of Psychiatry and Psychotherapy, University Hospital LMU Munich, Munich, Germany.
Mitja D BackInstitute of Psychology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0003-2186-1558
Nexhmedin MorinaInstitute of Psychology, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-2331-9140
Ulrike BuhlmannInstitute of Psychology, University of Münster, Münster, Germany.
Tilo KircherDepartment of Psychiatry, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-2514-2625
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0002-0623-3759
MBB consortium
FOR2107 consortium
PRONIA consortium
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-6541-3795
Nils OpelDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.ORCID http://orcid.org/0000-0003-4749-3298

Funding

Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 01EE2305CDeutsche Forschungsgemeinschaft (German Research Foundation) HA 7070/2-2, HA7070/3, HA7070/4Deutsche Forschungsgemeinschaft (German Research Foundation) RE4458/1-1
6 · The paper itself

Abstract

Concerns about the generalizability of machine learning models in mental health arise, partly due to sampling effects and data disparities between research cohorts and real-world populations. We aimed to investigate whether a machine learning model trained solely on easily accessible and low-cost clinical data can predict depressive symptom severity in unseen, independent datasets from various research and real-world clinical contexts. This observational multi-cohort study included 3021 participants (62.03% females, M

Indexed as

AdolescentAdultAgedAged, 80 and overCohort StudiesDepressionFemaleHumansMachine LearningMaleMental DisordersMental HealthMiddle AgedMood DisordersSeverity of Illness IndexYoung Adult

Identifiers

PMID40108256
PMCPMC12240828

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.