ArticleBMC psychiatry2025
Abnormalities in brain complexity in children with autism spectrum disorder: a sleeping state functional MRI study.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Automating region selection with genetic algorithms for energy landscape analyses of brain dynamics.Patterns (New York, N.Y.) · 2026Article
- Abnormal functional connectivity of dynamic brain network in toddlers with autism and its correlation with symptoms.BMC psychiatry · 2026Article
- Autism spectrum disorder disrupts brain network connectivity maturation during childhood development.Scientific reports · 2025Article
- Wired Differently? Brain Temporal Complexity and Intelligence in Autism Spectrum Disorder.Brain sciences · 2025Article
- Analysis of brain functional connectivity in children with autism spectrum disorder and sleep disorders: a fNIRS observational study.Frontiers in psychology · 2025Article
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Authors and funding
9 authors.
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Abstract
BACKGROUND AND
objectiveThe theory of complexity loss in neurodivergent brain is widely acknowledged. However, the findings of autism research do not seem to align well with this theory. We aim to investigate the brain complexity in children with ASD (Autism Spectrum Disorders) compared with the TD (Typical Developed) children in sleeping state.
method42 ASD children and 42 TD children were imaged using sleep-state functional magnetic resonance imaging (ss-fMRI), and brain complexity was analyzed by employing sample entropy (SampEn) and transfer entropy (TE). For the ASD group, we also investigated the relationship of symptom severity with SampEn and with TE.
resultsIn compared with TD group, ASD group showed significant increased SampEn in the right inferior frontal gyrus. However, in the group of TD, 13 pairs of brain regions exhibit higher TE compared to the ASD group. In the ASD group, the TE of 5 pairs of brain regions is higher than in the TD group.
conclusionThis sleeping-state fMRI study provide evidence that ASD children exhibited aberrant brain complexity in compare with the TD children. The complexity of the autistic brain is composed of aberrant randomness in brain activity and anomalous information transmission between brain regions. We believe that brain complexity in ASD is a highly valuable area of research. Differences in the entropy of local brain regions, as well as in the transfer entropy between brain regions, may be related to the brain complexity observed in children with ASD.
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