Evidence map›Paper›PMID 40108896›Full record

ReviewCurrent topics in medicinal chemistry2025

Natural Compounds and their Nano-formulations in Combating Autophagy-mediated Drug Resistance in Human Cancers.

Fahad Khan, Prashant Chauhan, Seema Ramniwas, Meenakshi Verma, Shivam Pandey, Suhas Ballal, Sanjay Kumar, Mahakshit Bhat, Shilpa Sharma, M Ravi Kumar and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current topics in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fahad KhanCenter for Global Health Research Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Prashant ChauhanMPA Research centre, Greater Noida, UP, India.
Seema RamniwasUniversity Centre of Research and Development, University institute of Biotechnology, Chandigarh University Gharuan, Mohali, Punjab, India.
Meenakshi VermaUniversity Centre of Research and Development, University institute of Biotechnology, Chandigarh University Gharuan, Mohali, Punjab, India.
Shivam PandeySchool of Applied and Life Sciences, Uttaranchal University, Dehradun.
Suhas BallalDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Sanjay KumarDepartment of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan-303012, India.
Mahakshit BhatDepartment of Medicine, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, India.
Shilpa SharmaChandigarh Pharmacy College, Chandigarh Group of Colleges- Jhanjeri, Mohali - 140307, Punjab, India.
M Ravi KumarDepartment of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh-531162, India.
Sorabh LakhanpalSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
Pratibha PandeyCentre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura- 140401, Punjab, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a crucial mechanism that maintains cellular homeostasis and has emerged as a pivotal factor in cancer progression and drug resistance. Despite autophagic regulations being a complex process, convincing evidence shows that PI3K-Akt-mTOR, LKB1-AMPK-mTOR, and p53 pathways are the primary upstream regulators of the autophagy process. Currently, there is an immense amount of evidence demonstrating that autophagy plays a crucial role in cancer. It is worth noting that autophagy increases cancer cells' resistance to chemotherapy and anticancerous drugs. According to studies, cancer cells employ autophagy to evade the cytotoxic impacts of several anticancer drugs, resulting in autophagy-mediated drug resistance. This resistance brings a significant challenge to cancer management, emphasising the need for improved therapeutic strategies to overcome this obstacle and enhance the efficacy of cancer treatments. Therefore, this review gathers current data and findings to understand the intricate mechanism between autophagymediated drug resistance and cancer progression. Moreover, this study highlights the intriguing role of natural compounds and nano-formulations in combating autophagy-mediated drug resistance in various carcinomas, presenting a promising avenue for the effective management of cancer treatment.

Indexed as

Antineoplastic AgentsAutophagyBiological ProductsDrug Resistance, NeoplasmNanoparticlesNeoplasmsHumansAntineoplastic AgentsBiological ProductsAutophagycancercellular homeostasis.drug resistancenano-formulationsnatural compound

Identifiers

PMID40108896

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.