Evidence map›Paper›PMID 40109009›Full record

ArticleChemistryOpen2025

Aqueous/Nonaqueous DBU Mixtures: Versatile Switching Media for Chemoselective Aldol, Baylis-Hillman, and Aldol Condensation Reactions.

Elaheh Akbarzadeh, M Saeed Abaee, Yazdanbakhsh L Nosood, Mohammad M Mojtahedi, Klaus Harms, Zahra Shabani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elaheh AkbarzadehDepartment of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Blvd., 17th Km, Tehran-Karaj Highway, P.O.Box 14335-186, Tehran, Iran.
M Saeed AbaeeDepartment of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Blvd., 17th Km, Tehran-Karaj Highway, P.O.Box 14335-186, Tehran, Iran.ORCID https://orcid.org/0000-0002-8254-4321
Yazdanbakhsh L NosoodDepartment of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Blvd., 17th Km, Tehran-Karaj Highway, P.O.Box 14335-186, Tehran, Iran.
Mohammad M MojtahediDepartment of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Blvd., 17th Km, Tehran-Karaj Highway, P.O.Box 14335-186, Tehran, Iran.ORCID https://orcid.org/0000-0001-6942-0650
Klaus HarmsFachbereich Chemie Philipps-Universitaet Marburg, Hans-Meerwein-Strasse, D-35032, Marburg, Germany.
Zahra ShabaniDepartment of Organic Chemistry and Natural Products, Chemistry and Chemical Engineering Research Center of Iran, Pajouhesh Blvd., 17th Km, Tehran-Karaj Highway, P.O.Box 14335-186, Tehran, Iran.

Funding

research council at ccerci 1402-112
6 · The paper itself

Abstract

Isophorone is a relatively small molecule with several neighboring reacting sites, making it susceptible to various competing reactions with aldehydes, including aldol, Baylis-Hillman (BH), aldol condensation, and Michael addition reactions. In the present work, we have designed a switchable 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed procedure, where the reaction of isophorone with aldehydes is guided chemoselectively toward either aldol, BH, or aldol condensation reactions, depending on the use of water and/or heat. This controllable divergency likely stems from the ability to tune the dual nucleophilicity/basicity characters of the DBU/H

Indexed as

Aldol condensationBaylis-Hillman reactionChemoselective reactionsDBUSwitching media

Identifiers

PMID40109009
PMCPMC12820351

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.