Evidence map›Paper›PMID 40109474›Full record

ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Mechanisms by Which Paraventricular Hypothalamic Nucleus Participates in the Acupuncture Treatment of Diseases].

Ziyou Bai, Chaoran Zhang, Yiqing Rao, Qishun Lin, Lingling Yu, Jiabao Liu, Xianghong Jing, Man Li

Abstract readReviewEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ziyou Bai（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Chaoran Zhang（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Yiqing Rao（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Qishun Lin（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Lingling Yu（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Jiabao Liu（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Xianghong Jing（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Man Li（ 430030） Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, a growing body of research has demonstrated that acupuncture can be used to effectively treat a diverse range of diseases, including functional gastrointestinal disorders, cardiovascular diseases, as well as anxiety and depression, through the modulation of the paraventricular hypothalamic nucleus (PVN). Acupuncture may exert its therapeutic effect either by modulating specific neurons within the PVN, such as corticotropin releasing hormone (CRH) neurons, or by regulating the release of hormones, such as oxytocin (OXT) and vasopressin (VP), and the activity of neural circuits associated with the PVN. This review summarizes the mechanisms by which PVN is involved in acupuncture treatment, including its regulatory mechanisms in gastrointestinal diseases, cardiovascular diseases, and negative emotions and pain. Future research should be conducted to further explore the precise mechanisms by which acupuncture regulates PVN to treat diseases, focusing on clarifying the specific processes of signaling pathway transduction, and exploring the specific effects of acupunture of different acupoint combinations and stimulation frequencies and intensity on PVN.

Indexed as

Acupuncture TherapyGastrointestinal DiseasesParaventricular Hypothalamic NucleusAnimalsCorticotropin-Releasing HormoneHumansOxytocinCorticotropin-Releasing HormoneOxytocinAcupunctureGastrointestinal tractHeart diseaseHypertensionParaventricular hypothalamic nucleusReview

Identifiers

PMID40109474
PMCPMC11914022

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.