ArticleFrontiers in medicine2025
Timing of transcutaneous acupoint electrical stimulation for postoperative recovery in geriatric patients with gastrointestinal tumors: study protocol for a randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05482477 (Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor：a Protocol of Randomised Controlled Trial), which is not on this map. Cited by 3 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor：a Protocol of Randomised Controlled Trial
Who cites it
3 citing papers in PubMed.
- Effect of transcutaneous electrical acupoint stimulation on post-anesthetic shivering: a meta-analysis and trial sequential analysis.Annals of medicine and surgery (2012) · 2026Article
- Evidence-based acupuncture: Methodological insights and challenges in gastroenteroscopy recovery research.World journal of gastroenterology · 2026Article
- Bridging Traditions: Integrating TCM Into ERAS for Enhanced Gastrointestinal Recovery -A Scoping Review.Drug design, development and therapy · 2026Article
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4 authors.
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Abstract
Purpose: To develop a study protocol for determining the optimal timing of Transcutaneous Electrical Acupoint Stimulation (TEAS) to enhance postoperative recovery in elderly patients. The study aims to evaluate different timing strategies for TEAS administration and their effects on postoperative outcomes, with the goal of improving clinical practices and guiding future research. Methods: A total of 266 geriatric patients who underwent radical resection of gastrointestinal tumors will be divided into seven groups: one control group (receiving standardized perioperative management), one sham intervention group (receiving TEAS treatment without electrical stimulation), and five intervention groups (receiving TEAS at different time intervals). The intervention groups will receive TEAS at bilateral Neiguan (PC6) and Zusanli (ST36) acupoints. The TEAS treatment will employ an altered frequency of 2/100 Hz with disperse-dense waveforms and an adjustable intensity, ensuring the stimulation remains below 10 mA and within a tolerable range for the patient. The device will output an asymmetrical biphasic pulse wave, with a pulse width of 0.2 ms ± 30%, based on electromagnetic compatibility basic performance testing. The primary outcome will assess changes in cognition, measured using neuropsychological tests administered preoperatively and 3 days postoperatively, as well as the Telephone Interview for Cognitive Status-Modified (TICS-m) at 1, 3, and 6 months postoperatively. Secondary outcomes will include preoperative and 3-day postoperative measurements of interleukin-6 (IL-6), S100 calcium-binding protein β (S100β), tumor necrosis factor alpha (TNF- Discussion: This protocol aims to determine the optimal timing of TEAS for improving postoperative recovery in geriatric patients with gastrointestinal tumor. Clinical trial registration: ClinicalTrials.gov, identifier NCT05482477.
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