Evidence map›Paper›PMID 40109739›Full record

ArticleACS pharmacology & translational science2025

Development of a Novel

Jian Rong, Chunyu Zhao, Ahmad F Chaudhary, Jiahui Chen, Xin Zhou, Kuo Zhang, Zhendong Song, Zhenkun Sun, Yabiao Gao, Zachary Zhang and 7 more

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Head-to-head comparison of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4-Targeted Probe.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Preclinical development of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Radiosynthesis and Evaluation ofACS medicinal chemistry letters · 2026
    Article
  5. Quantitative analysis of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Radiosynthesis and evaluation of anAmerican journal of nuclear medicine and molecular imaging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jian RongDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0002-3960-1669
Chunyu ZhaoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Ahmad F ChaudharyDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0001-9186-1110
Xin ZhouDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Kuo ZhangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Zhenkun SunDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Yabiao GaoDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Zachary ZhangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Siyan FengDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Thomas Lee CollierDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Jimmy S PatelDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Achi HaiderDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0009-0005-3704-0908
Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0003-1413-6315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholesterol 24-hydroxylase (CYP46A1), also known as CH24H, is a brain-specific monooxygenase responsible for the elimination of cholesterol from the central nervous system (CNS). It catalyzes the conversion of cholesterol to 24(

Identifiers

PMID40109739
PMCPMC11915032

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.