ReviewCureus2025
A Systematic Review of the Accuracy and Reliability of Pyuria in Diagnosing Pediatric Urinary Tract Infections.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infections (UTIs) are among the most common bacterial infections during childhood. Early diagnosis and prompt treatment are necessary to prevent long-term sequelae. Pyuria, a key diagnostic marker for UTIs, is defined as the presence of ≥5 white blood cells per high-power field in urine obtained by centrifugation of urine and microscopic analysis. However, there is a debate around pyuria's role in UTI diagnosis, which highlights the need for a comprehensive evaluation of its diagnostic accuracy in pediatric settings. This study aims to evaluate the diagnostic accuracy of pyuria as a marker for UTIs in pediatric patients by analyzing the sensitivity, specificity, and various factors affecting the diagnostic performance of pyuria and the alignment of these findings with the current clinical guidelines of pediatric UTI management. A comprehensive search was conducted through the following electronic databases: PubMed, Central, and Science Direct. The articles underwent a two-phase filtration process: first by title and abstract and second by full text, conducted by two independent reviewers. Data was extracted using a Google form (Google LLC, Mountain View, CA, USA) covering study details, participant characteristics, biomarkers, and diagnostic methods. The methodological quality of the studies was assessed using the National Institutes of Health tool, and the detailed protocol is available on PROSPERO (CRD42023399392). Our search yielded 491 results, with 18 studies meeting the inclusion criteria. The mean age across the studies was 2.7 years, and the majority of patients were females.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.