Evidence map›Paper›PMID 40109875›Full record

ArticleCurrent research in toxicology2025

The impact of in utero tobacco exposure on smoking behaviors, cardiovascular disease risk and all-cause mortality in adulthood: A UK Biobank study.

Yanxu Zheng, Xinyu Xiong, Jing Bao, Jingyu Liu, Jin Wang, Fang Zou, Zixi Chen, Yang Guo, Qingyao Wang, Yixuan Qiu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yanxu ZhengCardiovascular Department, The Second Xiangya Hospital, Central South University, Hunan 410011, China.
Xinyu XiongCardiovascular Department, The Second Xiangya Hospital, Central South University, Hunan 410011, China.
Jing BaoCardiovascular Department, The Second Xiangya Hospital, Central South University, Hunan 410011, China.
Jingyu LiuXiangya School of Medicine, Central South University, Hunan 410013, China.
Jin WangXiangya School of Medicine, Central South University, Hunan 410013, China.
Fang ZouXiangya School of Medicine, Central South University, Hunan 410013, China.
Zixi ChenXiangya School of Medicine, Central South University, Hunan 410013, China.
Yang GuoXiangya School of Medicine, Central South University, Hunan 410013, China.
Qingyao WangDepartment of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Yixuan QiuXiangya School of Medicine, Central South University, Hunan 410013, China.
Zhaowei ZhuCardiovascular Department, The Second Xiangya Hospital, Central South University, Hunan 410011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The knowledge regarding the negative impacts of in utero tobacco exposure (IUTE) on cardiovascular disease (CVD) was incomplete. This study aims to assess the association between IUTE and the risks of CVD incidence and all-cause mortality, discuss the inter-group difference based on genetic susceptibility and smoking behaviors after birth, and explore the potential mediating factors. Utilizing a total of 375,024 participants from the UK Biobank, the outcomes include myocardial infarction, stroke, chronic ischemic heart disease, nonrheumatic aortic valve disorders, cardiomyopathy, heart failure, atherosclerosis, aortic aneurysm and dissection, and all-cause mortality. During a median follow-up period of 14.6 years, 50,434 cases of CVD were recorded. IUTE was significantly associated with increased CVD incidence (HR 1.10, 95 % CI 1.08-1.12) and all-cause mortality (HR 1.11, 95 % CI 1.09-1.14). Interaction effects between IUTE, smoking behaviors after birth, and genetic risk scores for CVD were observed significant (P for interaction < 0.005). The results of the cross-sectional study revealed a significant positive association between IUTE and smoking behaviors after birth (OR 1.08, 95 % CI 1.06-1.09). Mediation analysis indicated that smoking behaviors (Proportion = 12.40 %, P < 0.001) and HDL-c levels (Proportion = 14.20 %, P < 0.001) partially mediated the IUTE-CVD relationship. This study demonstrated that individuals with IUTE have a higher risk of developing CVD, and smoking behaviors after birth have multifaceted influence on this correlation. These findings underscore the importance of mothers avoiding smoking during pregnancy to mitigate adverse effects on their offspring.

Indexed as

All-cause mortalityCardiovascular diseaseGenetic susceptibilityIn utero tobacco exposureSmoking behaviors

Identifiers

PMID40109875
PMCPMC11919589

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.